PMID- 18035003 OWN - NLM STAT- MEDLINE DCOM- 20080226 LR - 20170214 IS - 0300-0605 (Print) IS - 0300-0605 (Linking) VI - 35 IP - 6 DP - 2007 Nov-Dec TI - Melkersson-Rosenthal syndrome with isolated immunoglobulin E hypogammaglobulinaemia. PG - 922-5 AB - Melkersson-Rosenthal syndrome (MRS) is a rare disorder classically presenting with a triad of recurrent orofacial swelling, facial palsy and a fissured tongue. This case report describes a case of MRS in a patient with isolated immunoglobulin E (IgE) hypogammaglobulinaemia. The 52-year-old woman presented with puffy eyelids, lower lip swelling and right facial nerve palsy. Fissures of the tongue were also noted. On investigation she was found to have a markedly low serum IgE level. This case report clearly indicates that IgE-mediated reactions do not play a significant role in the development of MRS. FAU - Nakane, T AU - Nakane T AD - Department of Paediatrics, Faculty of Medicine, University of Yamanashi, Chuo, Japan. Tnakane99@aol.com FAU - Hatakeyama, K AU - Hatakeyama K FAU - Nakamura, K AU - Nakamura K FAU - Aihara, M AU - Aihara M FAU - Nakazawa, S AU - Nakazawa S LA - eng PT - Case Reports PT - Journal Article PL - England TA - J Int Med Res JT - The Journal of international medical research JID - 0346411 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Agammaglobulinemia/*immunology MH - Female MH - Humans MH - Immunoglobulin E/*deficiency MH - *Melkersson-Rosenthal Syndrome/diagnosis/immunology/physiopathology MH - Middle Aged EDAT- 2007/11/24 09:00 MHDA- 2008/02/27 09:00 CRDT- 2007/11/24 09:00 PHST- 2007/11/24 09:00 [pubmed] PHST- 2008/02/27 09:00 [medline] PHST- 2007/11/24 09:00 [entrez] AID - 10.1177/147323000703500623 [doi] PST - ppublish SO - J Int Med Res. 2007 Nov-Dec;35(6):922-5. doi: 10.1177/147323000703500623.