PMID- 18036065
OWN - NLM
STAT- MEDLINE
DCOM- 20080215
LR  - 20221207
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 8
IP  - 6
DP  - 2007 Dec
TI  - Dyslipidemia and other cardiovascular risk factors in a Canadian First Nation 
      pediatric population with type 2 diabetes mellitus.
PG  - 384-90
AB  - OBJECTIVE: The objectives of this study were to describe the prevalence of 
      dyslipidemia in a population of youth with type 2 diabetes mellitus (T2DM) and to 
      examine the relationship between the lipid parameters and other known 
      cardiovascular risk factors. METHODS: Ninety-nine youth aged 7-17 yr with T2DM 
      had a fasting blood sample for lipid and lipoprotein levels [total cholesterol, 
      low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein 
      cholesterol, triglycerides (TG)], apolipoprotein B (apoB), blood glucose, and 
      hemoglobin A1c (HbA1(C)). Lipid profiles were compared with a non-diabetic 
      population of Canadian First Nation (FN) youth and to published reference data. 
      Rates of obesity, hypertension, smoking, and poor glycemic control were recorded 
      and the relationship between these cardiovascular risk factors and lipid patterns 
      was analyzed. RESULTS: Fifty-seven percent of the subjects were female and 95% 
      were of self-declared FN heritage. The mean levels of all components of the lipid 
      profile were elevated in the group with T2DM compared with the control population 
      (p < 0.001). ApoB levels exceeded the 75th %ile of the control population in 72% 
      of those with T2DM. Thirty-seven percent of those with T2DM had elevated TG and 
      apoB levels. Forty percent were smokers. Fifty-nine percent had an HbA1(C) that 
      was greater than 7.0%. Thirty-nine percent had a BMI z-score >/= 2 but less than 
      15% had systolic hypertension. CONCLUSIONS: Atherogenic lipid profiles are common 
      in youth with T2DM. Elevated apoB levels with normal LDL-c levels highlight the 
      importance of a full lipid panel including apoB in defining potential modifiable 
      cardiovascular risk in this population with high rates of obesity, smoking, and 
      poor glycemic control.
FAU - Sellers, Elizabeth A C
AU  - Sellers EA
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, 
      Manitoba, Canada. esellers@exchange.hsc.mb.ca
FAU - Yung, Grant
AU  - Yung G
FAU - Dean, Heather J
AU  - Dean HJ
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
CIN - Pediatr Diabetes. 2007 Dec;8(6):349-51. PMID: 18036058
CIN - Pediatr Diabetes. 2007 Dec;8(6):352-3. PMID: 18036059
MH  - Adolescent
MH  - Canada/epidemiology
MH  - Cardiovascular Diseases/*etiology
MH  - Case-Control Studies
MH  - Child
MH  - Diabetes Mellitus, Type 2/blood/*complications/*epidemiology
MH  - Dyslipidemias/*etiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Population Groups/statistics & numerical data
MH  - Risk Factors
EDAT- 2007/11/27 09:00
MHDA- 2008/02/19 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/02/19 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - PDI284 [pii]
AID - 10.1111/j.1399-5448.2007.00284.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2007 Dec;8(6):384-90. doi: 10.1111/j.1399-5448.2007.00284.x.