PMID- 18036188
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20230829
IS  - 1538-7836 (Electronic)
IS  - 1538-7836 (Linking)
VI  - 6
IP  - 3
DP  - 2008 Mar
TI  - C reactive protein and its determinants in healthy men and women from European 
      regions at different risk of coronary disease: the IMMIDIET Project.
PG  - 436-43
AB  - AIM: Differences in C-reactive protein (CRP) levels and its determinants in three 
      European populations at different risk of coronary artery disease (CAD) were 
      studied. METHODS: Subjects were recruited randomly in Limburg (Belgium), Abruzzo 
      (Italy) and south-west (SW) London (England). RESULTS: Ten-year risk of fatal 
      coronary events (estimated using risk equations provided by the SCORE Project) 
      was lower both in men and women from Abruzzo, intermediate in people from Limburg 
      and higher in subjects from SW London. Within each country, high sensitivity 
      (hs)-CRP levels were higher in the high-risk class in men but not in women. Men 
      from Abruzzo had higher hs-CRP levels than those from Limburg and SW London. 
      Women always had higher hs-CRP levels than men. The strongest hs-CRP determinant 
      was body mass index (BMI, R(2) = 0.14) in women and waist circumference (WC, R(2) 
      = 0.046) in men. The highest hs-CRP levels were observed in subjects with both 
      high BMI and high WC. Metabolic syndrome was associated with high levels of CRP 
      both in men and women, even after adjustment for confounders. DISCUSSION: 
      Difference in CRP levels cannot explain the European gradient of CVD risk, 
      although CRP levels are associated with the calculated SCORE risk of fatal 
      coronary events within each country.
FAU - Arcari, A
AU  - Arcari A
AD  - Research Laboratories, John Paul II Centre for High Technology Research and 
      Education in Biomedical Sciences, Catholic University, Campobasso, Italy.
FAU - Zito, F
AU  - Zito F
FAU - Di Castelnuovo, A
AU  - Di Castelnuovo A
FAU - De Curtis, A
AU  - De Curtis A
FAU - Dirckx, C
AU  - Dirckx C
FAU - Arnout, J
AU  - Arnout J
FAU - Cappuccio, F P
AU  - Cappuccio FP
FAU - van Dongen, M C J M
AU  - van Dongen MC
FAU - De Lorgeril, M
AU  - De Lorgeril M
FAU - Krogh, V
AU  - Krogh V
FAU - Siani, A
AU  - Siani A
FAU - Donati, M B
AU  - Donati MB
FAU - De Gaetano, G
AU  - De Gaetano G
FAU - Iacoviello, L
AU  - Iacoviello L
CN  - European Collaborative Group of Immidiet Project
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071123
PL  - England
TA  - J Thromb Haemost
JT  - Journal of thrombosis and haemostasis : JTH
JID - 101170508
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Composition
MH  - Body Mass Index
MH  - C-Reactive Protein/*biosynthesis
MH  - Coronary Disease/*blood
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood
MH  - Middle Aged
MH  - Reference Values
MH  - Risk
MH  - White People
EDAT- 2007/11/27 09:00
MHDA- 2008/06/18 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - S1538-7836(22)12809-6 [pii]
AID - 10.1111/j.1538-7836.2007.02851.x [doi]
PST - ppublish
SO  - J Thromb Haemost. 2008 Mar;6(3):436-43. doi: 10.1111/j.1538-7836.2007.02851.x. 
      Epub 2007 Nov 23.