PMID- 18036315
OWN - NLM
STAT- MEDLINE
DCOM- 20080630
LR  - 20171116
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 87
IP  - 34
DP  - 2007 Sep 11
TI  - [Correlation between the function of monocytes/macrophages and disease 
      progression in people living with HIV/AIDS in several provinces in China].
PG  - 2394-7
AB  - OBJECTIVE: To investigate the functional states of peripheral blood 
      monocytes/macrophages and their relation with the disease progression in people 
      living with HIV/AIDS (PWHA). METHODS: Peripheral blood samples were collected 
      from 57 PWHA who didn't receive antivirus treatment before and 32 healthy 
      controls in Jilin, Liaoning, and Henan provinces. Flow cytometry was used to 
      detect the expression of the early activation molecule CD69 in the CD14(+) cells. 
      The plasma HIV RNA level was determined using real-time PCR. RESULTS: The CD69 
      expression rate in the CD14(+) T cells of the PWHA group was 27% +/- 4%, 
      significantly higher than that of the controls (P < 0.01). The CD69 expression 
      rate of the AIDS group was 39% +/- 3%, significantly higher than those of the HIV 
      group and long-term nonprogressors (LTNP) group (26% +/- 3% and 20% +/- 4% 
      respectively, both P < 0.05), that of the HIV groups being significantly higher 
      than that of the LTNP group too (P < 0.05). The side scatter value of the CD14(+) 
      T cells of the PWHA group was 76 +/- 16, significantly higher than that of the 
      control group (50 +/- 12, P < 0.05). The monocyte/macrophage CD69 expression rate 
      was significantly negatively correlated with the absolute value of CD4(+) T cells 
      (r = -0.872, P < 0.01), and not correlated with the value of CD8(+) T cells (P > 
      0.05). The monocyte/macrophage CD69 expression rate was significantly positively 
      correlated with the HIV-1 RNA viral load (r = 0.697, P < 0.01). CONCLUSION: The 
      activation and the phagocytosis function of the monocytes/macrophages of the PWHA 
      in China are higher than those of the healthy control. They are positively 
      correlated with the disease progression.
FAU - Zhou, Li-ping
AU  - Zhou LP
AD  - Key Laboratory of Immunology of AIDS, Ministry of Health, First Hospital, China 
      Medical University, Shenyang 110001, China.
FAU - Shang, Hong
AU  - Shang H
FAU - Zhang, Zi-ning
AU  - Zhang ZN
FAU - Wang, Ya-nan
AU  - Wang YN
FAU - Li, Ge-fei
AU  - Li GF
FAU - Shi, Wan-ying
AU  - Shi WY
FAU - Ding, Hai-bo
AU  - Ding HB
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD69 antigen)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*blood/immunology/virology
MH  - Adult
MH  - Antigens, CD/blood
MH  - Antigens, Differentiation, T-Lymphocyte/blood
MH  - CD4 Antigens/blood
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - China
MH  - Female
MH  - Flow Cytometry
MH  - HIV Infections/*blood/immunology/virology
MH  - Humans
MH  - Lectins, C-Type
MH  - Lipopolysaccharide Receptors/blood
MH  - Macrophages/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - RNA, Viral/blood
MH  - Viral Load
EDAT- 2007/11/27 09:00
MHDA- 2008/07/01 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/07/01 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2007 Sep 11;87(34):2394-7.