PMID- 18036345
OWN - NLM
STAT- MEDLINE
DCOM- 20080305
LR  - 20091119
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 581
IP  - 30
DP  - 2007 Dec 22
TI  - Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression 
      via ERK pathway in mouse NIH-3T3 fibroblasts.
PG  - 5743-50
AB  - Intact osteoactivin, a novel type I membrane glycoprotein, were shed at a dibasic 
      motif in the juxtamembrane region in C2C12 myoblasts. Extracellular fragments 
      were secreted into the culture media by a putative metalloprotease. Extracellular 
      fragments of osteoactivin, but not control protein, induced matrix 
      metalloprotease-3 (MMP-3) expression in NIH-3T3 fibroblasts. Epidermal growth 
      factor (ERK) kinase inhibitors inhibited the osteoactivin-mediated MMP-3 
      expression, whereas the extracellular fragment of osteoactivin activated ERK1/2 
      and p38 in the mitogen-activated protein kinase pathway. Our results suggest that 
      the extracellular fragments of osteoactivin produced by shedding act as a growth 
      factor to induce MMP-3 expression via the ERK pathway in fibroblasts.
FAU - Furochi, Harumi
AU  - Furochi H
AD  - Department of Nutritional Physiology, Institute of Health Biosciences, The 
      University of Tokushima Graduate School, Tokushima, Japan.
FAU - Tamura, Seiko
AU  - Tamura S
FAU - Mameoka, Mai
AU  - Mameoka M
FAU - Yamada, Chiharu
AU  - Yamada C
FAU - Ogawa, Takayuki
AU  - Ogawa T
FAU - Hirasaka, Katsuya
AU  - Hirasaka K
FAU - Okumura, Yuushi
AU  - Okumura Y
FAU - Imagawa, Takahito
AU  - Imagawa T
FAU - Oguri, Sachiko
AU  - Oguri S
FAU - Ishidoh, Kazumi
AU  - Ishidoh K
FAU - Kishi, Kyoichi
AU  - Kishi K
FAU - Higashiyama, Shigeki
AU  - Higashiyama S
FAU - Nikawa, Takeshi
AU  - Nikawa T
LA  - eng
PT  - Journal Article
DEP - 20071126
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Eye Proteins)
RN  - 0 (Gpnmb protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protease Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Enzyme Induction/drug effects
MH  - Eye Proteins/chemistry/*metabolism/pharmacology
MH  - Fibroblasts/cytology/drug effects/*enzymology
MH  - Male
MH  - Matrix Metalloproteinase 3/*biosynthesis/genetics
MH  - Membrane Glycoproteins/chemistry/*metabolism/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitogen-Activated Protein Kinase 1/*metabolism
MH  - Mitogen-Activated Protein Kinase 3/*metabolism
MH  - Muscle, Skeletal/drug effects/enzymology
MH  - NIH 3T3 Cells
MH  - Peptide Fragments/chemistry/*metabolism/pharmacology
MH  - Protease Inhibitors/pharmacology
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/genetics/metabolism
MH  - Up-Regulation/drug effects
EDAT- 2007/11/27 09:00
MHDA- 2008/03/06 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/10/18 00:00 [received]
PHST- 2007/10/18 00:00 [revised]
PHST- 2007/11/12 00:00 [accepted]
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/03/06 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - S0014-5793(07)01180-5 [pii]
AID - 10.1016/j.febslet.2007.11.036 [doi]
PST - ppublish
SO  - FEBS Lett. 2007 Dec 22;581(30):5743-50. doi: 10.1016/j.febslet.2007.11.036. Epub 
      2007 Nov 26.