PMID- 18037740
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 71
IP  - 12
DP  - 2007 Dec
TI  - Osteopontin expression of circulating T cells and plasma osteopontin levels are 
      increased in relation to severity of heart failure.
PG  - 1879-84
AB  - BACKGROUND: T cells in peripheral blood reflect the systemic inflammatory 
      response in patients with heart failure (HF). In a rat model of HF, osteopontin 
      is dramatically increased in the left ventricular myocardium, so the association 
      between osteopontin and HF was examined in the present study. METHODS AND 
      RESULTS: Peripheral blood was collected from 93 patients with heart disease and 
      38 controls. Left ventricular ejection fraction (LVEF) was calculated using a 
      modified Simpson's rule. The 93 patients were classified into 3 classes according 
      to the New York Heart Association (NYHA) functional classification. 
      Osteopontin-expressing CD4+ T cells were quantified by flow cytometry. Plasma 
      osteopontin levels (ng/ml) and the frequencies of osteopontin-expressing CD4+ T 
      cells (%) were higher in patients with HF than in controls (800+/-554, 575+/-229, 
      p=0.016 and 27.3+/-12.2, 16.7+/-10.0, p<0.001). Furthermore, the plasma 
      osteopontin levels and the frequencies of osteopontin-expressing CD4+ T cells 
      increased in proportion to the severity of the NYHA functional class. The 
      frequencies of osteopontin-expressing CD4+ T cells were significantly correlated 
      with LVEF (r=-0.336, p=0.0048) and log plasma brain natriuretic peptide levels 
      (r=0.305, p=0.0025). CONCLUSIONS: Osteopontin expression of circulating CD4+ T 
      cells and plasma osteopontin levels reflect the severity of HF. Osteopontin could 
      be a new target in the assessment of HF.
FAU - Soejima, Hirofumi
AU  - Soejima H
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Japan. yuuki@gpo.kumamoto-u.ac.jp
FAU - Irie, Atsushi
AU  - Irie A
FAU - Fukunaga, Takashi
AU  - Fukunaga T
FAU - Oe, Yoko
AU  - Oe Y
FAU - Kojima, Sunao
AU  - Kojima S
FAU - Kaikita, Koichi
AU  - Kaikita K
FAU - Kawano, Hiroaki
AU  - Kawano H
FAU - Sugiyama, Seigo
AU  - Sugiyama S
FAU - Yoshimura, Michihiro
AU  - Yoshimura M
FAU - Kishikawa, Hideki
AU  - Kishikawa H
FAU - Nishimura, Yasuharu
AU  - Nishimura Y
FAU - Ogawa, Hisao
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 106441-73-0 (Osteopontin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - CD4-Positive T-Lymphocytes/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/*blood/classification/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteopontin/blood/*metabolism
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Stroke Volume/physiology
EDAT- 2007/11/27 09:00
MHDA- 2008/02/13 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - JST.JSTAGE/circj/71.1879 [pii]
AID - 10.1253/circj.71.1879 [doi]
PST - ppublish
SO  - Circ J. 2007 Dec;71(12):1879-84. doi: 10.1253/circj.71.1879.