PMID- 18037819
OWN - NLM
STAT- MEDLINE
DCOM- 20080409
LR  - 20220318
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 56
IP  - 2-3
DP  - 2007
TI  - Serum BDNF levels in suicide attempters related to psychosocial stressors: a 
      comparative study with depression.
PG  - 93-7
AB  - Although many studies have examined the neurobiological aspects of suicide, the 
      molecular mechanisms and pathophysiologic mechanisms associated with suicide 
      remain unclear. In this study, it is aimed to investigate whether there is a 
      difference in serum brain-derived neurotrophic factor (BDNF) levels among suicide 
      attempters without a major psychiatric disorder, compared to major depressive 
      disorder patients and healthy subjects. It was undertaken with the hypothesis 
      that suicide per se lowers serum BDNF levels, since it is a source of stress. The 
      study was carried out in Celal Bayar University Hospital, Manisa, Turkey. Ten 
      suicide attempters, 24 patients with major depressive disorder and 26 subjects 
      without any psychiatric diagnosis and any psychiatric treatment were included in 
      the study. All subjects were asked to give their written consent. Blood samples 
      were collected at the baseline. Serum BDNF was kept at -70 degrees C before 
      testing, and assayed with an ELISA kit (Promega; Madison, Wisc., USA) after 
      dilution with the block and sample solution provided with the kit. The data were 
      subjected to the Kruskal-Wallis test for nonparametric analysis of variance. Mean 
      serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 
      ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the 
      control group (31.4 +/- 8.8 ng/ml; p = 0.004). These results suggest that BDNF 
      may play an important role in the neurobiology of suicidal behavior. BDNF levels 
      may be a biological marker for suicidal behavior. To investigate the role of BDNF 
      in suicide, further studies with a wider sample size and a variety of psychiatric 
      diagnoses accompanying suicide attempt are needed.
CI  - 2007 S. Karger AG, Basel
FAU - Deveci, Artuner
AU  - Deveci A
AD  - Department of Psychiatry, Faculty of Medicine, Celal Bayar University, Manisa, 
      Turkey. artuner.d@superonline.com
FAU - Aydemir, Omer
AU  - Aydemir O
FAU - Taskin, Oryal
AU  - Taskin O
FAU - Taneli, Fatma
AU  - Taneli F
FAU - Esen-Danaci, Aysen
AU  - Esen-Danaci A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071123
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Statistics, Nonparametric
MH  - Stress, Psychological/*blood
MH  - Suicide, Attempted/*psychology
EDAT- 2007/11/27 09:00
MHDA- 2008/04/10 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/02/23 00:00 [received]
PHST- 2007/09/13 00:00 [accepted]
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/04/10 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - 000111539 [pii]
AID - 10.1159/000111539 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2007;56(2-3):93-7. doi: 10.1159/000111539. Epub 2007 Nov 23.