PMID- 18038392
OWN - NLM
STAT- MEDLINE
DCOM- 20080505
LR  - 20071126
IS  - 1932-6254 (Print)
IS  - 1932-6254 (Linking)
VI  - 1
IP  - 1
DP  - 2007 Jan-Feb
TI  - Multipotent adult progenitor cell transplantation increases vascularity and 
      improves left ventricular function after myocardial infarction.
PG  - 51-9
AB  - Progressive contractile dysfunction of viable myocardium that surrounds a large 
      infarct leads to heart failure following acute myocardial infarction (AMI). 
      Experimental evidence indicates that cellular transplantation may improve the 
      left ventricular (LV) contractile performance, even though the underlying 
      mechanisms remain undefined. Here, we compared the effect of transplantation of 
      murine multipotent adult progenitor cells (MAPCs), a population of adult bone 
      marrow-derived cells that differentiate into cells of mesodermal, endodermal and 
      ectodermal origin, with murine bone marrow cells (BMCs) or fibroblasts on 
      post-infarct cardiac function by peri-infarct injection after coronary artery 
      ligation in mice. We demonstrate that, in contrast to the other cell populations, 
      transplantation of MAPCs significantly improved LV contractile function for at 
      least 8 weeks post-transplantation and, although BMCs reduced infarct size, the 
      decrease in scar size was substantially greater in MAPC-treated hearts. As 
      neither MAPCs nor BMCs were present beyond 1 week, the beneficial effect was not 
      due to differentiation and direct contribution of MAPCs to the vascular or 
      cardiomyocyte compartment. Significantly more inflammatory cells were present in 
      MAPC- than BMC-treated hearts at 1 week, which was accompanied by increased 
      vascularity 8 weeks post-transplantation. We hypothesize that MAPCs indirectly 
      contributed to these effects, by secreting inflammatory [monocyte chemoattractant 
      protein-1 (MCP)-1], and vascular growth factors [vascular endothelial growth 
      factor (VEGF), platelet-derived growth factor (PDGF)-BB, and transforming growth 
      factor (TGF)beta(1)), and others, resulting in increased angiogenensis and 
      cardioprotection.
CI  - 2007 John Wiley & Sons, Ltd
FAU - Pelacho, Beatriz
AU  - Pelacho B
AD  - Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 
      55455, USA.
FAU - Nakamura, Yasuhiro
AU  - Nakamura Y
FAU - Zhang, Jianyi
AU  - Zhang J
FAU - Ross, Jeff
AU  - Ross J
FAU - Heremans, Yves
AU  - Heremans Y
FAU - Nelson-Holte, Molly
AU  - Nelson-Holte M
FAU - Lemke, Brad
AU  - Lemke B
FAU - Hagenbrock, Julianna
AU  - Hagenbrock J
FAU - Jiang, Yuehua
AU  - Jiang Y
FAU - Prosper, Felipe
AU  - Prosper F
FAU - Luttun, Aernout
AU  - Luttun A
FAU - Verfaillie, Catherine M
AU  - Verfaillie CM
LA  - eng
GR  - R01 HL67828/HL/NHLBI NIH HHS/United States
GR  - R01 HL69119/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
SB  - IM
EIN - J Tissue Eng Regen Med. 2007 Jul-Aug;1(4):325
MH  - Aging/*physiology
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Mice
MH  - Myocardial Infarction/pathology/*physiopathology/*surgery
MH  - *Stem Cell Transplantation
MH  - Ventricular Function, Left/*physiology
EDAT- 2007/11/27 09:00
MHDA- 2008/05/06 09:00
CRDT- 2007/11/27 09:00
PHST- 2007/11/27 09:00 [pubmed]
PHST- 2008/05/06 09:00 [medline]
PHST- 2007/11/27 09:00 [entrez]
AID - 10.1002/term.7 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2007 Jan-Feb;1(1):51-9. doi: 10.1002/term.7.