PMID- 18039243
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20181201
IS  - 0012-1622 (Print)
IS  - 0012-1622 (Linking)
VI  - 49
IP  - 12
DP  - 2007 Dec
TI  - Systematic review of hyperbaric oxygen therapy for cerebral palsy: the state of 
      the evidence.
PG  - 942-7
AB  - A systematic review of the evidence was conducted on the benefits and adverse 
      effects of hyperbaric oxygen treatment (HBOT) for cerebral palsy (CP). Studies of 
      any HBOT regimen in patients with CP were included except for case reports and 
      case series. Electronic databases (e.g. MEDLINE, EMBASE), professional society 
      databases, and reference lists were searched to identify studies. Study quality 
      was assessed using predefined criteria relevant to the study design. Two 
      randomized controlled trials and four observational studies were identified. Best 
      evidence came from a randomized controlled trial which found that HBOT at 1.75 
      atmospheres (atm) and 1.3 atm of room air resulted in similar improvements in 
      motor function (5-6%). Other outcomes also indicated no difference between the 
      HBOT and room air. Observational studies reported improvements in motor function 
      to a similar degree. Other evidence was insufficient to clarify the benefits 
      and/or adverse effects of HBOT for CP. Both HBOT and pressurized room air 
      resulted in improvements in motor function compared with baseline. Similar 
      improvements were seen in the observational studies. Children undergoing HBOT 
      were reported to experience adverse events, including seizures and the need for 
      ear pressure equalization tube placement, but the incidence was unclear. Future 
      research is needed to determine the efficacy of pressurized room air or 
      non-pressurized oxygen in equivalent amounts by mask, compared with standard 
      treatments.
FAU - McDonagh, Marian S
AU  - McDonagh MS
AD  - Department of Medical Informatics and Clinical Epidemiology, Oregon Health and 
      Science University, Portland, Oregon 97239-3098, USA. mcdonagh@ohsu.edu
FAU - Morgan, Diane
AU  - Morgan D
FAU - Carson, Susan
AU  - Carson S
FAU - Russman, Barry S
AU  - Russman BS
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
SB  - IM
MH  - Cerebral Palsy/*therapy
MH  - Child
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
RF  - 25
EDAT- 2007/11/28 09:00
MHDA- 2008/01/30 09:00
CRDT- 2007/11/28 09:00
PHST- 2007/11/28 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2007/11/28 09:00 [entrez]
AID - DMCN942 [pii]
AID - 10.1111/j.1469-8749.2007.00942.x [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2007 Dec;49(12):942-7. doi: 
      10.1111/j.1469-8749.2007.00942.x.