PMID- 18039679
OWN - NLM
STAT- MEDLINE
DCOM- 20080529
LR  - 20080331
IS  - 1465-3664 (Electronic)
IS  - 0142-6338 (Linking)
VI  - 54
IP  - 2
DP  - 2008 Apr
TI  - Helicobacter pylori infection and gastroesophageal reflux in asthmatic children.
PG  - 129-32
AB  - The aim of this article is to investigate the prevalence of Helicobacter pylori 
      (HP) infection, frequency of gastroesophageal reflux (GER), existence of atopy 
      and levels of serum immunoglobulin E (IgE) in children with bronchial asthma. One 
      hundred and thirty seven children who were diagnosed as bronchial asthma and/or 
      wheezy child aged between 1 and 17 years were enrolled into the study. Peripheral 
      venous blood samples were obtained to determine the total IgE and HP IgG antibody 
      levels. GER was evaluated by the scintigraphic method and the presence of atopy 
      was investigated by skin prick test. The study was conducted in 86 (62.8%) boys 
      and 51 (37.2%) girls. HP IgG antibody levels were found negative in 125 (91.2%) 
      and positive in 12 (8.8%) cases. GER was detected in 73 (53.7%) of the children. 
      Forty-one (37.3%) children were accepted as atopic according to skin prick test 
      results. The average total IgE levels of the participants was 168.89 +/- 270.76 
      IU/ml. A significant difference could not be determined related to GER, atopy 
      frequency and serum IgE levels between the cases who had HP antibody positivity 
      or not. The present findings suggest that the rate of HP antibody positivity is 
      low in patients with bronchial asthma and a significant difference could not be 
      determined in GER, and atopy between patients with positive and negative HP 
      antibodies. High atopy frequency found in our patient group raises the question 
      of whether allergic diseases can be protective against fecal-oral infectious 
      diseases.
FAU - Asilsoy, Suna
AU  - Asilsoy S
AD  - Dokuz Eylul University Hospital, Department of Pediatrics, Division of Allergy, 
      Inciralti, Izmir, Turkey. suna365@gmail.com
FAU - Babayigit, Arzu
AU  - Babayigit A
FAU - Olmez, Duygu
AU  - Olmez D
FAU - Uzuner, Nevin
AU  - Uzuner N
FAU - Karaman, Ozkan
AU  - Karaman O
FAU - Oren, Oguz
AU  - Oren O
FAU - Turgut, Canan Sule
AU  - Turgut CS
FAU - Tezcan, Dilek
AU  - Tezcan D
LA  - eng
PT  - Journal Article
DEP - 20071125
PL  - England
TA  - J Trop Pediatr
JT  - Journal of tropical pediatrics
JID - 8010948
RN  - 0 (Antibodies, Bacterial)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Bacterial/*isolation & purification
MH  - Asthma/*etiology/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gastroesophageal Reflux/*complications/epidemiology/immunology
MH  - Helicobacter pylori/*immunology/pathogenicity
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Infant
MH  - Male
MH  - Seroepidemiologic Studies
MH  - Turkey
EDAT- 2007/11/28 09:00
MHDA- 2008/05/30 09:00
CRDT- 2007/11/28 09:00
PHST- 2007/11/28 09:00 [pubmed]
PHST- 2008/05/30 09:00 [medline]
PHST- 2007/11/28 09:00 [entrez]
AID - fmm069 [pii]
AID - 10.1093/tropej/fmm069 [doi]
PST - ppublish
SO  - J Trop Pediatr. 2008 Apr;54(2):129-32. doi: 10.1093/tropej/fmm069. Epub 2007 Nov 
      25.