PMID- 18040077
OWN - NLM
STAT- MEDLINE
DCOM- 20080402
LR  - 20231213
IS  - 0022-1554 (Print)
IS  - 1551-5044 (Electronic)
IS  - 0022-1554 (Linking)
VI  - 56
IP  - 3
DP  - 2008 Mar
TI  - Dendritic cell populations in colon and mesenteric lymph nodes of patients with 
      Crohn's disease.
PG  - 233-41
AB  - Dendritic cells (DCs) are key cells in innate and adaptive immune responses that 
      determine the pathophysiology of Crohn's disease. Intestinal DCs migrate from the 
      mucosa into mesenteric lymph nodes (MLNs). A number of different markers are 
      described to define the DC populations. In this study we have identified the 
      phenotype and localization of intestinal and MLN DCs in patients with Crohn's 
      disease and non-IBD patients based on these markers. We used immunohistochemistry 
      to demonstrate that all markers (S-100, CD83, DC-SIGN, BDCA1-4, and CD1a) showed 
      a different staining pattern varying from localization in T-cell areas of lymph 
      follicles around blood vessels or single cells in the lamina propria and in the 
      MLN in the medullary cords and in the subcapsular sinuses around blood vessels 
      and in the T-cell areas. In conclusion, all different DC markers give variable 
      staining patterns so there is no marker for the DC.
FAU - Verstege, Marleen I
AU  - Verstege MI
AD  - Centre for Experimental and Molecular Medicine, Academic Medical Centre, 
      Amsterdam, The Netherlands. m.i.verstege@amc.uva.nl
FAU - ten Kate, Fiebo J W
AU  - ten Kate FJ
FAU - Reinartz, Susanne M
AU  - Reinartz SM
FAU - van Drunen, Cornelis M
AU  - van Drunen CM
FAU - Slors, Frederik J M
AU  - Slors FJ
FAU - Bemelman, Willem A
AU  - Bemelman WA
FAU - Vyth-Dreese, Florry A
AU  - Vyth-Dreese FA
FAU - te Velde, Anje A
AU  - te Velde AA
LA  - eng
PT  - Journal Article
DEP - 20071126
PL  - United States
TA  - J Histochem Cytochem
JT  - The journal of histochemistry and cytochemistry : official journal of the 
      Histochemistry Society
JID - 9815334
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Surface)
RN  - 0 (Biomarkers)
RN  - 0 (CD1C protein, human)
RN  - 0 (CD1a antigen)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (S100 Proteins)
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/metabolism
MH  - Antigens, CD1/metabolism
MH  - Antigens, Surface/metabolism
MH  - Biomarkers/metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - Colon/metabolism/*pathology
MH  - Crohn Disease/metabolism/*pathology
MH  - Dendritic Cells/metabolism/*pathology
MH  - Glycoproteins
MH  - Humans
MH  - Immunoglobulins/metabolism
MH  - Immunohistochemistry
MH  - Intestinal Mucosa/metabolism/*pathology
MH  - Lectins, C-Type/metabolism
MH  - Lymph Nodes/metabolism/*pathology
MH  - Membrane Glycoproteins/metabolism
MH  - Mesentery
MH  - Middle Aged
MH  - Receptors, Cell Surface/metabolism
MH  - S100 Proteins/metabolism
MH  - Thrombomodulin
MH  - CD83 Antigen
PMC - PMC2324179
EDAT- 2007/11/28 09:00
MHDA- 2008/04/03 09:00
PMCR- 2009/03/01
CRDT- 2007/11/28 09:00
PHST- 2007/11/28 09:00 [pubmed]
PHST- 2008/04/03 09:00 [medline]
PHST- 2007/11/28 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - jhc.7A7308.2007 [pii]
AID - 7308 [pii]
AID - 10.1369/jhc.7A7308.2007 [doi]
PST - ppublish
SO  - J Histochem Cytochem. 2008 Mar;56(3):233-41. doi: 10.1369/jhc.7A7308.2007. Epub 
      2007 Nov 26.