PMID- 18041586
OWN - NLM
STAT- MEDLINE
DCOM- 20080828
LR  - 20211020
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 53
IP  - 8
DP  - 2008 Aug
TI  - Protective effects of diets supplemented with omega-3 polyunsaturated fatty acids 
      and calcium against colorectal tumor formation.
PG  - 2177-82
AB  - This study is to evaluate the effect of dietary omega-3 polyunsaturated fatty 
      acid (omega-3 PUFA) and/or calcium supplementation on colon tissue of the 
      carcinogenic N-methyl-N-nitrosurea (NMU)-injected rats and to investigate this 
      effect by the assessment of the oxidative stress. The rats were divided into four 
      groups: those fed with a standard diet, with a diet supplemented by omega-3 PUFA, 
      those fed with a diet with calcium, and those fed with a standard diet with the 
      combination of omega-3 PUFA and calcium. Rats were injected with an intrarectal 
      NMU. After 32 weeks, colon tissue specimens and plasma were taken to 
      histopathologically investigate and analyze tissue superoxide dismutase (SOD) and 
      glutathione peroxidase (GSH-px) activities and erythrocyte MDA levels. The tumor 
      incidences in supplemented-diet groups II and IV were found to be significantly 
      lower when compared with those of the controls (P < 0.05). Superoxide dismutase 
      and glutathione peroxidase antioxidative enzyme activities in colorectal tissue 
      were increased in the study groups when compared with control rats (P < 0.001) 
      and MDA levels were significantly lower than in the controls (P < 0.001) while 
      the levels in group IV were rather decreased than those in group III (P = 0.011). 
      These results suggest that the dietary supplementation of PUFA and/or calcium may 
      be useful in the prevention of colorectal tumor formation.
FAU - Kenar, Levent
AU  - Kenar L
AD  - Department of Clinical Biochemistry, Gulhane School of Medicine, Etlik, Ankara, 
      Turkey. lkenar@gata.edu.tr
FAU - Karayilanoglu, Turan
AU  - Karayilanoglu T
FAU - Aydin, Ahmet
AU  - Aydin A
FAU - Serdar, Muhittin
AU  - Serdar M
FAU - Kose, Songul
AU  - Kose S
FAU - Erbil, M Kemal
AU  - Erbil MK
LA  - eng
PT  - Journal Article
DEP - 20071128
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Calcium Compounds)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 684-93-5 (Methylnitrosourea)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Calcium Compounds/*pharmacology
MH  - Colon/*drug effects/enzymology/metabolism
MH  - Colorectal Neoplasms/chemically induced/metabolism/*prevention & control
MH  - *Dietary Supplements
MH  - Disease Models, Animal
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Male
MH  - Malondialdehyde/blood
MH  - Methylnitrosourea
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Inbred F344
MH  - Superoxide Dismutase/metabolism
MH  - Up-Regulation
EDAT- 2007/11/29 09:00
MHDA- 2008/08/30 09:00
CRDT- 2007/11/29 09:00
PHST- 2007/08/09 00:00 [received]
PHST- 2007/10/27 00:00 [accepted]
PHST- 2007/11/29 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2007/11/29 09:00 [entrez]
AID - 10.1007/s10620-007-0107-8 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2008 Aug;53(8):2177-82. doi: 10.1007/s10620-007-0107-8. Epub 2007 
      Nov 28.