PMID- 18042534
OWN - NLM
STAT- MEDLINE
DCOM- 20080204
LR  - 20220331
IS  - 0964-7058 (Print)
IS  - 0964-7058 (Linking)
VI  - 16
IP  - 4
DP  - 2007
TI  - Anemia and intestinal parasite infection in school children in rural Vietnam.
PG  - 716-23
AB  - OBJECTIVES: This study hypothesized that besides iron deficiency, intestinal 
      parasites infection is also a determinant of anemia in schoolchildren in rural 
      Vietnam. METHODS: 400 primary schoolchildren from 20 primary schools in Tam Nong 
      district, a poor rural area in Vietnam, were randomly selected from enrollment 
      lists. Venous blood (5ml) was collected in a cross sectional study and analyzed 
      for hemoglobin (Hb), serum ferritin (SF), serum transferrin receptor (TfR), serum 
      C-reactive protein (CRP) and total immunoglobulin E (IgE). Stools samples were 
      examined for hookworm, Trichuris, and Ascaris infection. Logistic regression was 
      used to assess the effect of intestinal parasites on anemia. RESULTS: The 
      prevalence of anemia (Hb < 115g/l) was 25%. Iron deficiency (TfR > 8.5mg/L) 
      occurred in 2% of the children. The prevalence of intestinal parasites was 92% 
      with the highest prevalence for Trichuris (76%) and Ascaris (71%). More than 30% 
      and 80% of the children showed an elevated CRP (> or = 8 mg/L) and IgE (> 90 
      IU/ml) concentration. Anemia status was borderline significantly associated with 
      SF and not associated with TfR and CRP. The prevalence odds ratio for Trichuris 
      infection was 1.96 (95% CI 1.07-3.59) and 2.00 (95% CI 1.08-3.65) with iron 
      deficiency reflected by TfR and SF, respectively. CONCLUSION: Anemia is highly 
      prevalent among schoolchildren in Vietnam but may not be associated with iron 
      deficiency. Trichuris infection is associated with a doubled risk of anemia, not 
      mediated through iron deficiency. Chronic infection may play a role in anemia, 
      but needs further investigation.
FAU - Le, Huong Thi
AU  - Le HT
AD  - Nutrition Department, Hanoi Medical University, Vietnam. huong.lethi@wur.nl
FAU - Brouwer, Inge D
AU  - Brouwer ID
FAU - Verhoef, Hans
AU  - Verhoef H
FAU - Nguyen, Khan Cong
AU  - Nguyen KC
FAU - Kok, Frans J
AU  - Kok FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
RN  - 0 (Hemoglobins)
RN  - 0 (Receptors, Transferrin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Anemia/epidemiology/etiology
MH  - Anemia, Iron-Deficiency/epidemiology/*etiology
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Cross-Sectional Studies
MH  - Feces/*parasitology
MH  - Female
MH  - Ferritins/analysis
MH  - *Health Surveys
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Intestinal Diseases, Parasitic/*complications/epidemiology
MH  - Iron/*blood
MH  - Iron Deficiencies
MH  - Logistic Models
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Receptors, Transferrin/analysis
MH  - Rural Health
MH  - Vietnam/epidemiology
EDAT- 2007/11/29 09:00
MHDA- 2008/02/05 09:00
CRDT- 2007/11/29 09:00
PHST- 2007/11/29 09:00 [pubmed]
PHST- 2008/02/05 09:00 [medline]
PHST- 2007/11/29 09:00 [entrez]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2007;16(4):716-23.