PMID- 18043150
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20071128
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 53
IP  - 6
DP  - 2007 Nov-Dec
TI  - The pediatric mechanical circulatory support program in Innsbruck, Austria, and 
      the impact of such programs on lack of donor hearts in Europe.
PG  - 696-700
AB  - Strategy and results of the Innsbruck Mechanical Circulatory Support Program are 
      presented, and the impact of such programs on pediatric heart transplantation 
      (HTX) in Europe is discussed. Venoarterial extracorporeal membrane oxygenation 
      (vaECMO) and ventricular assist devices (VADs) were used in 21 pediatric patients 
      (median age 3.3 years, 2 days to 17 years) for acute heart failure (AHF) 
      following a bridge or bridge-to-bridge strategy. Twelve patients were treated 
      with vaECMO: eight were weaned after 2-10 days, two died, and two were switched 
      to a VAD. Of the last, one was weaned 47 days later and the other underwent HTX 
      168 days later. In nine patients, VAD was implanted without preceding vaECMO. One 
      such patient died (cerebral hemorrhage) after 236 days; of the remaining eight 
      patients three were weaned and five underwent HTX. Waiting time for HTX 
      (high-urgency status) varied from 4 to 372 days. Fifteen patients were discharged 
      (follow up: 2-74 months); 14 are doing very well (New York Heart Association 
      (NYHA) Functional Classification Class I, neurologically normal), whereas one 
      suffers from severe neurologic damage, presumably from resuscitation before 
      vaECMO. Data from Eurotransplant on pediatric HTX in 2004, 2005, and 2006 (33, 
      49, and 34 transplanted hearts, respectively; recipients <16 years of age) are 
      discussed. Mechanical circulatory support (MCS) substantially improves survival 
      with AHF in pediatric patients. Medium-term support (up to 400 days in our 
      patients) is possible and outcome of survivors is excellent. Wide spread use of 
      MCS might slightly aggravate the lack of donor organs, which could result in 
      longer support times.
FAU - Schweigmann, Ulrich
AU  - Schweigmann U
AD  - Department of Pediatrics III-Pediatric Cardiology, Innsbruck Medical University, 
      Innsbruck, Austria.
FAU - Antretter, Herwig
AU  - Antretter H
FAU - Mair, Peter
AU  - Mair P
FAU - Velik-Salchner, Corinna
AU  - Velik-Salchner C
FAU - Margreiter, Josef
AU  - Margreiter J
FAU - Brunnemann, Jorrit
AU  - Brunnemann J
FAU - Schermer, Elisabeth
AU  - Schermer E
FAU - Engl, Georg
AU  - Engl G
FAU - Hoermann, Christoph
AU  - Hoermann C
FAU - Hoefer, Daniel
AU  - Hoefer D
FAU - Kilo, Juliane
AU  - Kilo J
FAU - Laufer, Guenther
AU  - Laufer G
FAU - Stein, Joerg-Ingolf
AU  - Stein JI
FAU - Geiger, Ralf
AU  - Geiger R
FAU - Rahmel, Axel
AU  - Rahmel A
FAU - Slot, Marjan
AU  - Slot M
FAU - Cottogni, Marco
AU  - Cottogni M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Acute Disease
MH  - Austria
MH  - Child, Preschool
MH  - Europe
MH  - Extracorporeal Membrane Oxygenation/instrumentation
MH  - Follow-Up Studies
MH  - Heart Failure/therapy
MH  - Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Time Factors
MH  - Tissue Donors/*supply & distribution
MH  - Treatment Outcome
MH  - Waiting Lists
EDAT- 2007/11/29 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/11/29 09:00
PHST- 2007/11/29 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/11/29 09:00 [entrez]
AID - 00002480-200711000-00012 [pii]
AID - 10.1097/MAT.0b013e3181569c09 [doi]
PST - ppublish
SO  - ASAIO J. 2007 Nov-Dec;53(6):696-700. doi: 10.1097/MAT.0b013e3181569c09.