PMID- 18043767
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20211020
IS  - 1180-4882 (Print)
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Linking)
VI  - 32
IP  - 6
DP  - 2007 Nov
TI  - In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan 
      during acute changes in mood states.
PG  - 430-4
AB  - BACKGROUND: Little is known about the specific contribution of serotonin (5-HT) 
      to the neurobiology of emotion and mood in healthy people. In an exploratory 
      study, we sought to investigate the effect of rapid and sustained changes of 
      emotional state on the trapping of 11C-labelled alpha-methyl-L-tryptophan 
      (11C-alphaMtrp) used as a proxy of 5-HT synthesis, using positron emission 
      tomography (PET). METHOD: In a within-subject repeated-measure design, 
      participants recalled autobiographical memories to self-induce sadness, happiness 
      and a neutral emotional state during scanning to measure brain trapping of 
      11C-alphaMtrp. Three separate scan acquisitions, counterbalanced for order across 
      subjects, took place at the McConnell Brain Imaging Center, Montreal. RESULTS: 
      Whole brain analysis revealed positive and negative correlations between 
      experienced levels of emotions and 11C-alphaMtrp trapping in the right anterior 
      cingulate cortex. CONCLUSION: These findings point to a mechanism whereby 
      state-related changes in a proxy of 5-HT synthesis underscore aspects of the 
      self-regulation of normal mood.
FAU - Perreau-Linck, Elisabeth
AU  - Perreau-Linck E
AD  - Perreau-Linck, Beauregard, Paquette-Department of Psychology, University of 
      Montreal, Que.
FAU - Beauregard, Mario
AU  - Beauregard M
FAU - Gravel, Paul
AU  - Gravel P
FAU - Paquette, Vincent
AU  - Paquette V
FAU - Soucy, Jean-Paul
AU  - Soucy JP
FAU - Diksic, Mirko
AU  - Diksic M
FAU - Benkelfat, Chawki
AU  - Benkelfat C
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
RN  - 13510-08-2 (alpha-methyltryptophan)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
CIN - J Psychiatry Neurosci. 2007 Nov;32(6):394-9. PMID: 18043762
MH  - Adult
MH  - Affect/*physiology
MH  - Brain/*metabolism
MH  - Humans
MH  - Male
MH  - *Positron-Emission Tomography
MH  - Serotonin/biosynthesis
MH  - Tryptophan/*analogs & derivatives/metabolism
PMC - PMC2077345
OTO - NOTNLM
OT  - brain
OT  - depression
OT  - emotions
OT  - gyrus, cingulate
OT  - positron emission tomography
OT  - serotonin
OT  - tryphophan
EDAT- 2007/11/29 09:00
MHDA- 2008/02/20 09:00
PMCR- 2007/11/01
CRDT- 2007/11/29 09:00
PHST- 2007/11/29 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/11/29 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - 0001585-200711000-00006 [pii]
PST - ppublish
SO  - J Psychiatry Neurosci. 2007 Nov;32(6):430-4.