PMID- 18044139
OWN - NLM
STAT- MEDLINE
DCOM- 20071221
LR  - 20240416
IS  - 1176-9092 (Print)
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Linking)
VI  - 2
IP  - 2
DP  - 2007
TI  - Prevention and treatment of venous thromboembolism in the elderly patient.
PG  - 237-46
AB  - Venous thromboembolism (VTE) is a common complication among hospitalized 
      patients. Pharmacological thromboprophylaxis has emerged as the cornerstone for 
      VTE prevention. As trials on thromboprophylaxis in medical patients have proven 
      the efficacy of both low-molecular-weight heparins (LMWHs) and unfractionated 
      heparin (UFH), all acutely medical ill patients should be considered for 
      pharmacological thromboprophylaxis. Unlike in the surgical setting where the risk 
      of associated VTE attributable to surgery is well recognized, and where 
      widespread use of pharmacological thromboprophylaxis and early mobilization has 
      resulted in significant reductions in the risk of VTE, appropriate VTE 
      prophylaxis is under-used in medical patients. Many reasons for this under-use 
      have been identified, including low perceived risk of VTE in medical patients, 
      absence of optimal tools for risk assessment, heterogeneity of patients and their 
      diseases, and fear of bleeding complications. A consistent group among 
      hospitalized medical patients is composed of elderly patients with impaired renal 
      function, a condition potentially associated with bleeding. How these patients 
      should be managed is discussed in this review. Particular attention is devoted to 
      LMWHs and fondaparinux and to measures to improve the safety and the efficacy of 
      their use.
FAU - Tincani, Enrico
AU  - Tincani E
AD  - Unita Operativa di Medicina Interna Cardiovascolare, Nuovo Ospedale Civile di 
      Modena S. Agostino-Estense, Modena, Italy. e.tincani@ausl.mo.it
FAU - Crowther, Mark A
AU  - Crowther MA
FAU - Turrini, Fabrizio
AU  - Turrini F
FAU - Prisco, Domenico
AU  - Prisco D
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Polysaccharides)
RN  - 9005-49-6 (Heparin)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Aged
MH  - Anticoagulants/administration & dosage/adverse effects/*therapeutic use
MH  - Drug Monitoring
MH  - Fondaparinux
MH  - Guideline Adherence
MH  - Heparin/administration & dosage/adverse effects/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Humans
MH  - Polysaccharides/therapeutic use
MH  - Practice Guidelines as Topic
MH  - Renal Insufficiency/complications
MH  - Venous Thromboembolism/*drug therapy/*prevention & control
PMC - PMC2684509
EDAT- 2007/11/30 09:00
MHDA- 2007/12/22 09:00
PMCR- 2007/06/01
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2007/12/22 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - cia-2-237 [pii]
PST - ppublish
SO  - Clin Interv Aging. 2007;2(2):237-46.