PMID- 18044471
OWN - NLM
STAT- MEDLINE
DCOM- 20080115
LR  - 20091109
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 61
IP  - 4
DP  - 2007 Sep
TI  - [The relationship of periodontitis and diabetes mellitus].
PG  - 369-74
AB  - Periodontitis is a chronic, dental-plaque induced inflammatory disease of the 
      tooth-supporting tissues, resulting in a gradual loss of connective tissue 
      attachment and alveolar bone. The interrelationship between diabetes mellitus and 
      periodontitis has been studied for many years. At,present, there is strong 
      evidence to suggest that the incidence and severity of periodontitis is 
      influenced by the presence or absence of diabetes mellitus as well as by the 
      degree of diabetes control by patients. Elevated blood glucose levels in poorly 
      controlled diabetics result in an increase of protein glycosylation leading to 
      amplified formation of so-called Advanced Glycation End products (AGE). AGEs are 
      glucose products that have the ability to attract and stimulate inflammatory 
      cells to produce inflammatory cytokines, elevating the risk of periodontal 
      attachment and/or alveolar bone loss. Gram-negative periodontal infection 
      significantly decreases glucose tolerance and can lead, like other types of 
      inflammation, to an increase in the severity of diabetes. Thus, diabetes and 
      periodontal disease form a system in which periodontitis is aggravated and 
      metabolic control of blood glucose levels becomes more difficult. This in turn 
      leads to mutual aggravation that results in a self-enforcing catabolic process, a 
      vicious circle of inflammation, tissue destruction and insulin resistance.
FAU - Kasaj, Adrian
AU  - Kasaj A
AD  - Zavod za restorativnu stomatologiju i parodontologiju, Stomatoloski fakultet, 
      Sveuciliste u Mainzu, Mainz, Njemacka. kasaj@gmx.de
FAU - Gortan-Kasaj, Aristea
AU  - Gortan-Kasaj A
FAU - Willerhausen, Brita
AU  - Willerhausen B
FAU - Hoffmann, Oliver
AU  - Hoffmann O
FAU - Angelov, Nikola
AU  - Angelov N
FAU - Zafiropoulos, Gregory-George
AU  - Zafiropoulos GG
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Odnos parodontitisa i dijabetesa melitusa.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - Diabetes Complications/*physiopathology
MH  - Humans
MH  - Periodontitis/complications/*physiopathology
RF  - 81
EDAT- 2007/11/30 09:00
MHDA- 2008/01/16 09:00
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2008/01/16 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
PST - ppublish
SO  - Acta Med Croatica. 2007 Sep;61(4):369-74.