PMID- 18045139
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20190823
IS  - 0929-8673 (Print)
IS  - 0929-8673 (Linking)
VI  - 14
IP  - 27
DP  - 2007
TI  - Cochlear stem cells/progenitors and degenerative hearing disorders.
PG  - 2937-43
AB  - Hearing loss (deafness) affects approximately 250 million people globally. The 
      major cause of deafness is loss of hair cells and spiral ganglion neurons due to 
      aging, antibiotic use, noise exposure, and genetic defects. At the present time, 
      there is no effective method for restoration of hearing biologically. Cochlear 
      stem cells/progenitors (CSCs), quiescent in the organ of Corti, are excellent 
      candidates for restoration of cell types in the organ of Corti biologically. 
      However, little is known about the biology of CSCs and developmental cues for 
      CSCs to differentiate into hair cells and neurons at the present time. In this 
      article, we briefly reviewed the isolation of CSCs from the postnatal organ of 
      Corti in mice and their capability to differentiate into hair cells and neurons 
      in vitro under the guidance of a group of growth factors: sonic hedgehog (SHH), 
      epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic 
      factor (BDNF), herein termed SERB. The identification of CSCs and their 
      differentiation signals is potentially of clinical importance.
FAU - Lin, Jizhen
AU  - Lin J
AD  - Department of Otolaryngology, University of Minnesota, Minneapolis 55455, USA. 
      linxx004@tc.umn.edu
FAU - Feng, Ling
AU  - Feng L
FAU - Fukudome, Shinji
AU  - Fukudome S
FAU - Hamajima, Yuki
AU  - Hamajima Y
FAU - Huang, Tina
AU  - Huang T
FAU - Levine, Samuel
AU  - Levine S
LA  - eng
GR  - P30CD04660/CD/ODCDC CDC HHS/United States
GR  - R01008165/PHS HHS/United States
GR  - R03 CA107989/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
SB  - IM
MH  - Animals
MH  - *Cell Transplantation
MH  - Cochlea/*cytology
MH  - Hearing Loss/*therapy
MH  - Humans
MH  - *Stem Cells
RF  - 48
EDAT- 2007/11/30 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
AID - 10.2174/092986707782360051 [doi]
PST - ppublish
SO  - Curr Med Chem. 2007;14(27):2937-43. doi: 10.2174/092986707782360051.