PMID- 18045152
OWN - NLM
STAT- MEDLINE
DCOM- 20080207
LR  - 20231024
IS  - 1567-2026 (Print)
IS  - 1567-2026 (Linking)
VI  - 4
IP  - 4
DP  - 2007 Nov
TI  - Macrophage infiltration, lectin-like oxidized-LDL receptor-1, and monocyte 
      chemoattractant protein-1 are reduced by chronic HMG-CoA reductase inhibition.
PG  - 268-73
AB  - Statin reduces cerebrovascular events independent of its cholesterol lowering 
      effect. We hypothesized that statin inhibits early atherosclerotic change in 
      common carotid artery (CCA), and investigated its effect on lectin-like 
      oxidized-LDL receptor-1 (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) 
      expression, both of which are early atherosclerotic markers. Stroke-prone 
      spontaneous hypertensive rats (SHR-SP) of 8 weeks old were orally treated with 
      vehicle or simvastatin (20mg/kg) daily. After 4 weeks of simvastatin or vehicle 
      treatment, or 2 weeks of vehicle and 2 weeks of simvastatin treatment, CCA was 
      removed. LOX-1 and MCP-1 expression as well as macrophage infiltration were 
      histologically investigated. Lipid deposition was also investigated by Sudan III 
      staining. Simvastatin groups showed significantly smaller amount of lipid 
      deposition and LOX-1 and MCP-1 expression, independent of serum lipid levels. 
      Macrophage infiltration was also decreased. Reduction of cerebrovascular events 
      by statins may be brought by the direct inhibition of atherosclerotic change.
FAU - Tsuchiya, Atsushi
AU  - Tsuchiya A
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, 
      Okayama University, Japan. a-t1@cc.okayama-u.ac.jp
FAU - Nagotani, Shoko
AU  - Nagotani S
FAU - Hayashi, Takeshi
AU  - Hayashi T
FAU - Deguchi, Kentaro
AU  - Deguchi K
FAU - Sehara, Yoshihide
AU  - Sehara Y
FAU - Yamashita, Toru
AU  - Yamashita T
FAU - Zhang, HanZhe
AU  - Zhang H
FAU - Lukic, Violeta
AU  - Lukic V
FAU - Kamiya, Tatsushi
AU  - Kamiya T
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Dietary Fats)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/pathology/prevention & control
MH  - Carotid Artery, Common/metabolism
MH  - Chemokine CCL2/*metabolism
MH  - Cholesterol/blood
MH  - Cholesterol, Dietary/pharmacology
MH  - Depression, Chemical
MH  - Diet
MH  - Dietary Fats/pharmacology
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Immunohistochemistry
MH  - Leukocyte Count
MH  - Lipids
MH  - Macrophages/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Simvastatin/pharmacology
MH  - Triglycerides/blood
EDAT- 2007/11/30 09:00
MHDA- 2008/02/08 09:00
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2008/02/08 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
AID - 10.2174/156720207782446333 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2007 Nov;4(4):268-73. doi: 10.2174/156720207782446333.