PMID- 18045174
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 13
IP  - 31
DP  - 2007
TI  - Therapeutic approaches in vascular repair induced by adult bone marrow cells and 
      circulating progenitor endothelial cells.
PG  - 3245-51
AB  - Strong evidence indicates that bone marrow cells (BMCs) can contribute to the 
      healing process of injured vascular system via CXCR4/Thymosin beta4/Integrin 
      alpha4beta1/SDF-1 molecular pathways. We discuss the therapeutic approaches of 
      BMCs and circulating endothelial progenitor cells (EPCs) to restore 
      vascularization. Today some clinical trials employing BMCs in the treatment of 
      peripheral vascular diseases have been completed with encouraging results. When 
      large clinical controlled studies will be completed, the scientific community 
      will evaluate this novel and promising therapeutic approach. Although some basic 
      studies suggest the potential use of adult/somatic stem cell for vascular repair, 
      other stringent data suggest that this potential is dependent also on growth 
      factor synthesis rather than the formation of new arterial vessels. Considering 
      the limitations of adult stem cells especially in elderly subjects, our point of 
      view is that BMCs or exogenous BMC/EPC are candidate for adjunct cell-therapy 
      applications in vascular repair.
FAU - Napoli, Claudio
AU  - Napoli C
AD  - Department of General Pathology, Division of Clinical Pathology and Excellence 
      Research Center on Cardiovascular Diseases, 1st School of Medicine, II University 
      of Naples, Italy. claunap@tin.it
FAU - Balestrieri, Antonio
AU  - Balestrieri A
FAU - Ignarro, Louis J
AU  - Ignarro LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Bone Marrow Cells/metabolism
MH  - *Bone Marrow Transplantation
MH  - Clinical Trials as Topic
MH  - Combined Modality Therapy
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Peripheral Vascular Diseases/*therapy
MH  - *Stem Cell Transplantation
MH  - Stem Cells/metabolism
RF  - 92
EDAT- 2007/11/30 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
AID - 10.2174/138161207782341303 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2007;13(31):3245-51. doi: 10.2174/138161207782341303.