PMID- 18046338
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20181201
IS  - 0743-8346 (Print)
IS  - 0743-8346 (Linking)
VI  - 28
IP  - 1
DP  - 2008 Jan
TI  - Systemic fungal infection is associated with the development of retinopathy of 
      prematurity in very low birth weight infants: a meta-review.
PG  - 61-6
AB  - OBJECTIVE: To study the association between systemic fungal infection (SFI) and 
      the development of retinopathy of prematurity (ROP) and severe ROP in very low 
      birth weight (VLBW) infants by systematic review and meta-analysis. STUDY DESIGN: 
      A meta-review was performed using a fixed effects model. The exposure and 
      outcomes studied were SFI and all ROP/severe ROP, respectively in VLBW infants. 
      Results and effect sizes analyzed with Review Manager 4.2 software are expressed 
      as relative risk (RR), odds ratio (OR), risk difference (RD) and number needed to 
      harm (NNH) with 95% confidence intervals. RESULT: Data for severe ROP were 
      available from eight studies and on all ROP from seven of those eight studies. 
      Estimated gestational age ranged from 24.7+/-1.6 to 28.6+/-4 weeks and birth 
      weight from 673 (median) (range 426 to 995) to 1108+/-266 g (mean+/-s.d.). A 
      total of 261 of 303 babies with SFI had all ROP vs 1081 of 1648 babies without 
      SFI (OR 3.4(*), 2.34-4.95) and 118 of 330 babies with SFI had severe ROP vs 235 
      of 1951 babies without SFI (OR 4.06(*), 3.05-5.42). The NNH was 5.56(*) 
      (4.54-7.14) for all ROP and 4.54(*) (3.70 to 5.88) for severe ROP ((*) 
      P<0.00001). CONCLUSION: SFIs are associated with the development of all degrees 
      of ROP and severe ROP in VLBW infants.
FAU - Bharwani, S K
AU  - Bharwani SK
AD  - Department of Pediatrics, Division of Neonatology, University of Tennessee Health 
      Science Center, Memphis, TN 38103-2896, USA.
FAU - Dhanireddy, R
AU  - Dhanireddy R
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20071129
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
SB  - IM
MH  - Candidiasis/complications
MH  - Fungemia/*complications/microbiology
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Very Low Birth Weight
MH  - Odds Ratio
MH  - Retinopathy of Prematurity/*microbiology/pathology
MH  - Severity of Illness Index
EDAT- 2007/11/30 09:00
MHDA- 2008/03/05 09:00
CRDT- 2007/11/30 09:00
PHST- 2007/11/30 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2007/11/30 09:00 [entrez]
AID - 7211878 [pii]
AID - 10.1038/sj.jp.7211878 [doi]
PST - ppublish
SO  - J Perinatol. 2008 Jan;28(1):61-6. doi: 10.1038/sj.jp.7211878. Epub 2007 Nov 29.