PMID- 18046771 OWN - NLM STAT- MEDLINE DCOM- 20080429 LR - 20181201 IS - 0741-0395 (Print) IS - 0741-0395 (Linking) VI - 31 Suppl 1 DP - 2007 TI - Genetic association with rheumatoid arthritis-Genetic Analysis Workshop 15: summary of contributions from Group 2. PG - S12-21 AB - The papers in presentation group 2 of Genetic Analysis Workshop 15 (GAW15) conducted association analyses of rheumatoid arthritis data. The analyses were carried out primarily in the data provided by the North American Rheumatoid Arthritis Consortium (NARAC). One group conducted analyses in the data provided by the Canadian Rheumatoid Arthritis Genetics Study (CRAGS). Analysis strategies included genome-wide scans, the examination of candidate genes, and investigations of a region of interest on chromosome 18q21. Most authors employed relatively new methods, proposed extensions of existing methods, or introduced completely novel methods for aspects of association analysis. There were several common observations; a group of papers using a variety of methods found stronger association, on chromosomes 6 and 18 and in candidate gene PTPN22 among women with early onset. Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses. CI - (c) 2007 Wiley-Liss, Inc. FAU - Wilcox, Marsha A AU - Wilcox MA AD - i3 Drug Safety, 950 Winter Street, Waltham, MA 02451, USA. Marsha.Wilcox@i3DrugSafety.com FAU - Li, Zhong AU - Li Z FAU - Tapper, Will AU - Tapper W FAU - Browning, Sharon AU - Browning S FAU - Curtin, Karen AU - Curtin K FAU - Ding, Jie AU - Ding J FAU - Ding, Yuejing AU - Ding Y FAU - Gagnon, France AU - Gagnon F FAU - He, Qimei AU - He Q FAU - Kuo, Tai-Yue AU - Kuo TY FAU - Li, Mingyao AU - Li M FAU - Matthew, George AU - Matthew G FAU - Mei, Ling AU - Mei L FAU - Rao, Shaoqi AU - Rao S FAU - Shaw, Jim AU - Shaw J FAU - Wei, Zhi AU - Wei Z FAU - Yu, Zhaoxia AU - Yu Z FAU - Zhang, Weihua AU - Zhang W FAU - Zheng, Tian AU - Zheng T FAU - Zhu, Guohua AU - Zhu G LA - eng PT - Congress PL - United States TA - Genet Epidemiol JT - Genetic epidemiology JID - 8411723 RN - EC 3.1.3.48 (PTPN22 protein, human) RN - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22) SB - IM MH - Algorithms MH - Arthritis, Rheumatoid/*genetics MH - Chromosomes, Human, Pair 18 MH - Chromosomes, Human, Pair 6 MH - Genome, Human MH - Haplotypes MH - Humans MH - Phenotype MH - Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics EDAT- 2007/11/30 09:00 MHDA- 2008/04/30 09:00 CRDT- 2007/11/30 09:00 PHST- 2007/11/30 09:00 [pubmed] PHST- 2008/04/30 09:00 [medline] PHST- 2007/11/30 09:00 [entrez] AID - 10.1002/gepi.20276 [doi] PST - ppublish SO - Genet Epidemiol. 2007;31 Suppl 1:S12-21. doi: 10.1002/gepi.20276.