PMID- 18048094
OWN - NLM
STAT- MEDLINE
DCOM- 20080508
LR  - 20071224
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 88
IP  - 4
DP  - 2008 Feb
TI  - Repeated neonatal separation results in different neurochemical and behavioral 
      changes in adult male and female Mongolian gerbils.
PG  - 533-41
AB  - We assessed whether daily separation of Mongolian gerbils (Meriones unguiculatus) 
      from mothers and siblings during postnatal days 4-20 would produce behavioral and 
      neurochemical changes in adulthood that parallel some features of depression in 
      humans. Neonatal separation altered the behavior of adult females in the open 
      field test but not in the tail suspension test, and did not affect behavior of 
      males. Separated males, but not females, showed a significant decrease in 
      hippocampal brain derived neurotrophic factor (BDNF) relative to controls. 
      Western blot and optical densitometry measurements in the hippocampus did not 
      reveal significant group differences in synaptophysin levels in either sex, but 
      there was a tendency toward decreased levels of synaptophysin in the entire 
      hippocampus as well as the CA1 hippocampal subregion of separated males. Repeated 
      separation of neonates from mothers and siblings led to subtle behavioral and 
      neurochemical changes during adulthood that were expressed differently in male 
      and female gerbils.
FAU - Jaworska, Natalia
AU  - Jaworska N
AD  - Department of Psychology, Dalhousie University, Halifax, Nova Scotia, B3H 4J1, 
      Canada.
FAU - Dwyer, Suzanne M
AU  - Dwyer SM
FAU - Rusak, Benjamin
AU  - Rusak B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071026
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synaptophysin)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Behavior, Animal/*physiology
MH  - Blotting, Western
MH  - Body Weight/physiology
MH  - Brain Chemistry/*physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Densitometry
MH  - Female
MH  - Gerbillinae
MH  - Hindlimb Suspension/psychology
MH  - Hippocampus/metabolism/physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Pregnancy
MH  - Sex Characteristics
MH  - Social Isolation/*psychology
MH  - Substance P/metabolism/physiology
MH  - Synaptophysin/metabolism
EDAT- 2007/12/01 09:00
MHDA- 2008/05/09 09:00
CRDT- 2007/12/01 09:00
PHST- 2007/05/22 00:00 [received]
PHST- 2007/09/11 00:00 [revised]
PHST- 2007/10/19 00:00 [accepted]
PHST- 2007/12/01 09:00 [pubmed]
PHST- 2008/05/09 09:00 [medline]
PHST- 2007/12/01 09:00 [entrez]
AID - S0091-3057(07)00324-3 [pii]
AID - 10.1016/j.pbb.2007.10.012 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2008 Feb;88(4):533-41. doi: 10.1016/j.pbb.2007.10.012. 
      Epub 2007 Oct 26.