PMID- 18050371
OWN - NLM
STAT- MEDLINE
DCOM- 20080228
LR  - 20171116
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 34
IP  - 12
DP  - 2007 Dec
TI  - The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus 
      erythematosus.
PG  - 2412-6
AB  - OBJECTIVE: To investigate whether CD40 and CD40 ligand (CD40L) is expressed in 
      the skin of patients with subacute cutaneous lupus erythematosus (SCLE). METHODS: 
      Six female patients with SCLE were studied. Skin biopsies were obtained from 
      lesional and healthy sunprotected skin. Frozen sections were stained 
      immunohistochemically using monoclonal antibodies to CD4, CD40, and CD40L. As 
      controls we used 5 patients with discoid LE (DLE), 5 with dermatomyositis (DM), 3 
      with lichen planus (LP), and 2 with erythema multiforme (EM), as well as the 
      normal-appearing skin of 5 healthy volunteers. RESULTS: The CD40 was intensely 
      expressed in all SCLE, DLE, and DM lesions, and only focally in healthy 
      sunprotected skin specimens. The number of CD40+ cells in SCLE dermis was lower 
      than in DLE, similar to that in DM, LP and EM, and higher than in SCLE 
      sunprotected skin. CD40L+ cells infiltrated the SCLE, DLE, DM, LP, and EM 
      lesional dermis, and were more numerous in SCLE lesional skin than in SCLE 
      healthy sunprotected skin. CONCLUSION: We showed that the CD40/CD40L system may 
      represent an important pathway of induction of SCLE lesions. The expression of 
      such costimulatory system in healthy sunprotected skin also may signify that its 
      abnormal activation is constitutive in SCLE, as previously observed in systemic 
      LE.
FAU - Caproni, Marzia
AU  - Caproni M
AD  - Department of Dermatological Sciences, University of Florence, Florence, Italy.
FAU - Torchia, Daniele
AU  - Torchia D
FAU - Antiga, Emiliano
AU  - Antiga E
FAU - Giomi, Barbara
AU  - Giomi B
FAU - Mercuri, Michele
AU  - Mercuri M
FAU - Volpi, Walter
AU  - Volpi W
FAU - Fabbri, Paolo
AU  - Fabbri P
LA  - eng
PT  - Journal Article
DEP - 20071115
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (CD40 Antigens)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Adult
MH  - CD40 Antigens/biosynthesis/*immunology
MH  - CD40 Ligand/biosynthesis/*immunology
MH  - Case-Control Studies
MH  - Dermatomyositis/immunology
MH  - Erythema Multiforme/immunology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - Lichen Planus/immunology
MH  - Lupus Erythematosus, Cutaneous/*immunology
MH  - Lupus Erythematosus, Discoid/immunology
MH  - Skin/*immunology
EDAT- 2007/12/01 09:00
MHDA- 2008/02/29 09:00
CRDT- 2007/12/01 09:00
PHST- 2007/12/01 09:00 [pubmed]
PHST- 2008/02/29 09:00 [medline]
PHST- 2007/12/01 09:00 [entrez]
AID - 07/13/1129 [pii]
PST - ppublish
SO  - J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15.