PMID- 18051571
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20071205
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 42
IP  - 9
DP  - 2007 Sep
TI  - [Expression and clinical significance of Endostatin, vascular endothelial growth 
      factor and fibroblast growth factor basic-2 in laryngeal carcinoma].
PG  - 687-91
AB  - OBJECTIVE: To evaluate the expression and clinical significance of Endostatin, 
      vascular endothelial growth factor (VEGF) and fibroblast growth factor basic-2 
      (FGF-2) in the laryngeal squamous cell carcinoma (LSCC). METHODS: The expression 
      of Endostatin, VEGF and FGF-2 in 50 specimens of LSCC, 40 specimens of 
      para-carcinoma and 10 specimens of normal laryngeal tissues were examined by Flow 
      cytometry. RESULTS: Compared with para-carcinoma and normal laryngeal tissues, 
      the expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were 
      different in statistics (P < 0.05); the expression level and positive rate of 
      endostatin, VEGF, FGF-2 in LSCC are obviously higher than those in para-carcinoma 
      and normal laryngeal tissues. The expression level and positive rate of 
      Endostatin, VEGF, FGF-2 were no difference in statistics between para-carcinoma 
      and normal laryngeal tissues (P > 0.05). The expression level and positive rate 
      of Endostatin, VEGF, FGF-2 in LSCC were associated with lymphoid metastasis and 
      clinical stage, not associated with age, sex and clinical group. CONCLUSIONS: 
      Endostatin, VEGF and FGF-2 play important role in the incidence, development and 
      prognosis of the LSCC.
FAU - Liu, Wei-wei
AU  - Liu WW
AD  - Department of Otorhinolaryngology, The Four Affiliated Hospital of Hebei Medical 
      University, Shijiazhuang 050011, China. lwwczbj@163.com
FAU - Zhang, Shu-jun
AU  - Zhang SJ
FAU - Han, Guang-huai
AU  - Han GH
FAU - Shi, Hui-jing
AU  - Shi HJ
FAU - Wang, Jun-ge
AU  - Wang JG
FAU - Dong, Shu-ling
AU  - Dong SL
FAU - Li, Hong-xia
AU  - Li HX
FAU - Li, Guo-li
AU  - Li GL
FAU - Sun, Qi-fen
AU  - Sun QF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (Endostatins)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Endostatins/*metabolism
MH  - Female
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2007/12/07 09:00
MHDA- 2011/09/13 06:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Sep;42(9):687-91.