PMID- 18053005
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20240109
IS  - 0960-7412 (Print)
IS  - 0960-7412 (Linking)
VI  - 53
IP  - 2
DP  - 2008 Jan
TI  - Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling 
      de-etiolation in darkness.
PG  - 324-35
AB  - In many plants, photomorphogenesis is the default developmental program after 
      seed germination, and provides the key features that allow adaptation to light. 
      This program is actively repressed if germination occurs in the absence of light, 
      through a mechanism dependent on the E3 ubiquitin ligase activity that is encoded 
      in Arabidopsis by COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), which induces 
      proteolytic degradation of transcription factors necessary for light-regulated 
      development, such as HY5 (LONG HYPOCOTYL 5) and HYH (LONG HYPOCOTYL 5 HOMOLOG), 
      and stabilization of transcription factors that promote skotomorphogenesis, such 
      as PIF3 (PHYTOCHROME INTERACTING FACTOR 3). Seedlings deficient in gibberellin 
      (GA) synthesis or signaling display a de-etiolated phenotype when grown in 
      darkness, equivalent to the phenotype of cop1 mutants, which indicates that the 
      switch between photo- and skotomorphogenesis is also under hormonal control. Here 
      we provide evidence for the existence of crosstalk between GA and the 
      COP1-mediated pathway, and identify HY5 and the PIF family as nodes of a 
      regulatory network. This interaction occurs through distinct molecular 
      mechanisms, based on the observation that GA signaling regulates protein 
      stability of HY5, and the activity of PIF3.
FAU - Alabadi, David
AU  - Alabadi D
AD  - Instituto de Biologia Molecular y Celular de Plantas (CSIC-UPV), Av de los 
      Naranjos s/n, 46022-Valencia, Spain.
FAU - Gallego-Bartolome, Javier
AU  - Gallego-Bartolome J
FAU - Orlando, Leonardo
AU  - Orlando L
FAU - Garcia-Carcel, Laura
AU  - Garcia-Carcel L
FAU - Rubio, Vicente
AU  - Rubio V
FAU - Martinez, Cristina
AU  - Martinez C
FAU - Frigerio, Martin
AU  - Frigerio M
FAU - Iglesias-Pedraz, Juan Manuel
AU  - Iglesias-Pedraz JM
FAU - Espinosa, Ana
AU  - Espinosa A
FAU - Deng, Xing Wang
AU  - Deng XW
FAU - Blazquez, Miguel A
AU  - Blazquez MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071205
PL  - England
TA  - Plant J
JT  - The Plant journal : for cell and molecular biology
JID - 9207397
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Gibberellins)
RN  - 0 (HY5 protein, Arabidopsis)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PIF3 protein, Arabidopsis)
SB  - IM
MH  - Arabidopsis/*metabolism
MH  - Arabidopsis Proteins/*metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/*metabolism
MH  - Basic-Leucine Zipper Transcription Factors/*metabolism
MH  - Darkness
MH  - Gene Expression Regulation, Plant
MH  - Genes, Plant
MH  - Gibberellins/*metabolism
MH  - Light
MH  - Models, Biological
MH  - Morphogenesis
MH  - Nuclear Proteins/*metabolism
MH  - Seedlings/*metabolism
MH  - Signal Transduction
EDAT- 2007/12/07 09:00
MHDA- 2008/04/09 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - TPJ3346 [pii]
AID - 10.1111/j.1365-313X.2007.03346.x [doi]
PST - ppublish
SO  - Plant J. 2008 Jan;53(2):324-35. doi: 10.1111/j.1365-313X.2007.03346.x. Epub 2007 
      Dec 5.