PMID- 18054517
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20220419
IS  - 1359-6101 (Print)
IS  - 1359-6101 (Linking)
VI  - 19
IP  - 1
DP  - 2008 Feb
TI  - Dendritic cells and cytokines in immune rejection of cancer.
PG  - 93-107
AB  - Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity 
      and, thus, in the generation of a protective immune response against both 
      infectious diseases and tumors. The ability of DCs to prime and expand an immune 
      response is regulated by signals acting through soluble mediators, mainly 
      cytokines and chemokines. Understanding how cytokines influence DC functions and 
      orchestrate the interactions of DCs with other immune cells is strictly 
      instrumental to the progress in cancer immunotherapy. Herein, we will illustrate 
      how certain cytokines and immune stimulating molecules can induce and sustain the 
      antitumor immune response by acting on DCs. We will also discuss these 
      cytokine-DC interactions in the light of clinical results in cancer patients.
FAU - Ferrantini, Maria
AU  - Ferrantini M
AD  - Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale 
      Regina Elena, 299, 00161 Rome, Italy. maria.ferrantini@iss.it
FAU - Capone, Imerio
AU  - Capone I
FAU - Belardelli, Filippo
AU  - Belardelli F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071203
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Aminoquinolines)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (CPG-oligonucleotide)
RN  - 0 (Cancer Vaccines)
RN  - 0 (Cytokines)
RN  - 0 (Interferon-alpha)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Toll-Like Receptor 9)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - P1QW714R7M (Imiquimod)
SB  - IM
MH  - Adjuvants, Immunologic/physiology
MH  - Aminoquinolines/therapeutic use
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, Neoplasm/*immunology
MH  - Cancer Vaccines/therapeutic use
MH  - Cells, Cultured
MH  - Clinical Trials as Topic
MH  - CpG Islands/physiology
MH  - Cytokines/*physiology
MH  - Dendritic Cells/*immunology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use
MH  - Humans
MH  - Imiquimod
MH  - Immunotherapy
MH  - Interferon-alpha/therapeutic use
MH  - Neoplasms/*immunology/prevention & control
MH  - Oligodeoxyribonucleotides/therapeutic use
MH  - Toll-Like Receptor 9/agonists
RF  - 145
EDAT- 2007/12/07 09:00
MHDA- 2008/04/30 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - S1359-6101(07)00112-8 [pii]
AID - 10.1016/j.cytogfr.2007.10.003 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2008 Feb;19(1):93-107. doi: 
      10.1016/j.cytogfr.2007.10.003. Epub 2007 Dec 3.