PMID- 18055049
OWN - NLM
STAT- MEDLINE
DCOM- 20080410
LR  - 20221207
IS  - 0168-1605 (Print)
IS  - 0168-1605 (Linking)
VI  - 121
IP  - 1
DP  - 2008 Jan 15
TI  - Effect of oral administration of heat-killed Lactobacillus brevis SBC8803 on 
      total and ovalbumin-specific immunoglobulin E production through the improvement 
      of Th1/Th2 balance.
PG  - 1-10
AB  - We examined the effect of 59 strains of heat-killed Lactobacillus brevis on 
      interleukin (IL)-12 and interferon (IFN)-gamma production from mouse Peyer's 
      patch (PP) cells. L. brevis has a great variety of strains that induce the 
      production of these cytokines. Some L. brevis strains, which were selected for 
      their ability to induce a strong Th1 immune response, inhibited both total 
      immunoglobulin E (IgE) and antigen specific IgE production, and improved the 
      Th1/Th2 balance by enhancing IL-12 and IFN-gamma and inhibiting IL-4 production 
      from ovalbumin (OVA)-sensitized mouse splenocytes. Based on the results of this 
      screening, we selected L. brevis SBC8803 as a potent inhibitor of IgE production, 
      and investigated the effect of oral administration of heat-killed SBC8803 on IgE 
      production in OVA-sensitized mice. OVA-sensitized mice were fed SBC8803 0% 
      (control), 0.05%, or 0.5% added diet for 4 weeks during the period of the 
      experiment. Total and OVA-specific IgE in the serum of mice, which were fed the 
      0.5% added diet, was significantly lower than that of the control diet fed mice. 
      The IFN-gamma/IL-4 value, which represents the Th1/Th2 balance, from the 0.5% 
      added diet fed mice splenocytes was also significantly higher than that of the 
      control diet fed mouse splenocytes. Histamine release from OVA-sensitized mice 
      into sera that were induced by the intraperitoneal antigen challenge decreased 
      following the oral administration of SBC8803. The inhibition of IgE production 
      and histamine secretion by the oral administration of heat-killed SBC8803 was 
      probably due to the improvement of the Th1/Th2 balance toward Th1 dominance.
FAU - Segawa, Shuichi
AU  - Segawa S
AD  - Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., 10 Okatohme, 
      Yaizu, Shizuoka 425-0013, Japan. syuuichi.segawa@sapporobeer.co.jp
FAU - Nakakita, Yasukazu
AU  - Nakakita Y
FAU - Takata, Yoshihiro
AU  - Takata Y
FAU - Wakita, Yoshihisa
AU  - Wakita Y
FAU - Kaneko, Takafumi
AU  - Kaneko T
FAU - Kaneda, Hirotaka
AU  - Kaneda H
FAU - Watari, Junji
AU  - Watari J
FAU - Yasui, Hisako
AU  - Yasui H
LA  - eng
PT  - Journal Article
DEP - 20071101
PL  - Netherlands
TA  - Int J Food Microbiol
JT  - International journal of food microbiology
JID - 8412849
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Immunologic
MH  - Female
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunosuppression Therapy/*methods
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/biosynthesis
MH  - Levilactobacillus brevis/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/*immunology
MH  - Peyer's Patches/immunology
MH  - Spleen/immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
EDAT- 2007/12/07 09:00
MHDA- 2008/04/11 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/01/29 00:00 [received]
PHST- 2007/08/21 00:00 [revised]
PHST- 2007/10/23 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/04/11 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - S0168-1605(07)00558-2 [pii]
AID - 10.1016/j.ijfoodmicro.2007.10.004 [doi]
PST - ppublish
SO  - Int J Food Microbiol. 2008 Jan 15;121(1):1-10. doi: 
      10.1016/j.ijfoodmicro.2007.10.004. Epub 2007 Nov 1.