PMID- 18055263
OWN - NLM
STAT- MEDLINE
DCOM- 20080417
LR  - 20080118
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 14
IP  - 1
DP  - 2008 Jan
TI  - Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 
      transmission.
PG  - 12-9
AB  - Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is 
      becoming evident that different DC subsets at the sites of infection have 
      distinct roles. In the genital tissues, two different DC subsets are present: the 
      Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate 
      HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission 
      by clearing invading HIV-1 particles. However, this protective function of LCs is 
      dependent on the function of the C-type lectin Langerin: blocking Langerin 
      function by high virus concentrations enables HIV-1 transmission by LCs. Here, we 
      will discuss the molecular mechanisms involved in HIV-1 transmission and viral 
      clearance. A better understanding of these processes is crucial to understand and 
      develop strategies to combat transmission.
FAU - de Witte, Lot
AU  - de Witte L
AD  - Department of Molecular Cell Biology and Immunology, VU University Medical 
      Center, Amsterdam, The Netherlands.
FAU - Nabatov, Alexey
AU  - Nabatov A
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071204
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Antigens, CD)
RN  - 0 (CD207 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Antigens, CD/physiology
MH  - Cell Adhesion Molecules
MH  - Dendritic Cells/*physiology
MH  - HIV Infections/*transmission
MH  - Humans
MH  - Langerhans Cells/*physiology
MH  - Lectins, C-Type/physiology
MH  - Mannose-Binding Lectins/physiology
MH  - Receptors, Cell Surface
RF  - 55
EDAT- 2007/12/07 09:00
MHDA- 2008/04/18 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/08/24 00:00 [received]
PHST- 2007/11/08 00:00 [revised]
PHST- 2007/11/08 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/04/18 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - S1471-4914(07)00218-3 [pii]
AID - 10.1016/j.molmed.2007.11.001 [doi]
PST - ppublish
SO  - Trends Mol Med. 2008 Jan;14(1):12-9. doi: 10.1016/j.molmed.2007.11.001. Epub 2007 
      Dec 4.