PMID- 18056245
OWN - NLM
STAT- MEDLINE
DCOM- 20080125
LR  - 20211020
IS  - 0002-953X (Print)
IS  - 1535-7228 (Electronic)
IS  - 0002-953X (Linking)
VI  - 164
IP  - 12
DP  - 2007 Dec
TI  - Association between brain-derived neurotrophic factor Val66Met gene polymorphism 
      and progressive brain volume changes in schizophrenia.
PG  - 1890-9
AB  - OBJECTIVE: Factors underlying progressive brain volume changes in schizophrenia 
      remain poorly understood. The authors investigated whether a gene polymorphism 
      influencing neuroplasticity may contribute to longitudinal brain volume 
      alterations. METHOD: High-resolution magnetic resonance (MR) images of the whole 
      brain were obtained for 119 patients with recent-onset schizophrenia spectrum 
      disorders. Changes in brain volumes over an average of 3 years were compared 
      between brain-derived neurotrophic factor (BDNF) val66met genotype groupings. 
      Exploratory analyses were conducted to examine relationships between 
      antipsychotic treatment and brain volume changes as well as the effects of BDNF 
      genotype on changes in cognition and symptoms. RESULTS: Significant genotype 
      effects were observed on within-subject changes in volumes of frontal lobe gray 
      matter, lateral ventricles, and sulcal CSF. Met allele carriers had significantly 
      greater reductions in frontal gray matter volume, with reciprocal volume 
      increases in the lateral ventricles and sulcal (especially frontal and temporal) 
      CSF than Val homozygous patients. Independent of BDNF genotype, more 
      antipsychotic exposure between MRI scans correlated with greater volume 
      reductions in frontal gray matter, particularly among patients who were initially 
      treatment naive. There were no statistically significant genotype effects on 
      within-subject changes in cognition or symptoms. CONCLUSIONS: BDNF(Met) variant 
      may be one of several factors affecting progressive brain volume changes in 
      schizophrenia.
FAU - Ho, Beng-Choon
AU  - Ho BC
AD  - Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins 
      Drive, Iowa City, IA 52242, USA. beng-ho@uiowa.edu
FAU - Andreasen, Nancy C
AU  - Andreasen NC
FAU - Dawson, Jeffrey D
AU  - Dawson JD
FAU - Wassink, Thomas H
AU  - Wassink TH
LA  - eng
GR  - MH 43271/MH/NIMH NIH HHS/United States
GR  - MH 31593/MH/NIMH NIH HHS/United States
GR  - K23 MH068380/MH/NIMH NIH HHS/United States
GR  - MH 40856/MH/NIMH NIH HHS/United States
GR  - R01 MH040856/MH/NIMH NIH HHS/United States
GR  - K23 MH068380-01A2/MH/NIMH NIH HHS/United States
GR  - R01 MH031593/MH/NIMH NIH HHS/United States
GR  - R37 MH031593/MH/NIMH NIH HHS/United States
GR  - MH 68380/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Atrophy/pathology
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition Disorders/diagnosis/psychology
MH  - Female
MH  - Frontal Lobe/pathology
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging/statistics & numerical data
MH  - Male
MH  - Methionine/genetics
MH  - Neuronal Plasticity/genetics
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/drug therapy/*genetics/*pathology
MH  - Schizophrenic Psychology
MH  - Severity of Illness Index
MH  - Valine/genetics
PMC - PMC3062255
MID - NIHMS68120
EDAT- 2007/12/07 09:00
MHDA- 2008/01/26 09:00
PMCR- 2011/03/22
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/01/26 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PHST- 2011/03/22 00:00 [pmc-release]
AID - 164/12/1890 [pii]
AID - 10.1176/appi.ajp.2007.05111903 [doi]
PST - ppublish
SO  - Am J Psychiatry. 2007 Dec;164(12):1890-9. doi: 10.1176/appi.ajp.2007.05111903.