PMID- 18057480
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20231213
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Linking)
VI  - 44
IP  - 11
DP  - 2007 Nov
TI  - Cefpodoxime proxetil compared with cefixime for treatment of typhoid fever in 
      children.
PG  - 838-41
AB  - In order to evaluate clinical and bacteriological efficacy of Cefpodoxime 
      Proxetil (CP) in typhoid fever in comparison to cefixime (CF), we assessed 140 
      children with suspected typhoid fever. Fulfilling inclusion criteria finally 40 
      culture confirmed typhoid fever were allocated in randomized double blind 
      clinical trial (RCT) to receive therapy with either oral CP (16 mg/kg/day, n = 
      21) or oral CF (20 mg/kg/day, n = 19) for 10 days. The two groups were comparable 
      in their clinical and baseline characteristics. The clinical efficacy was similar 
      in the two groups with only 2 (one in each group) clinical failures and all 
      showing bacteriological eradication on subsequent blood culture. The time of 
      defervescence was comparable in both groups (4.87 Fluconazole Prophylaxis against 
      Fungal Colonization and Invasive Fungal Infection in Very Low Birth Weight 
      Infants 2.33 vs 4.27 +/- 2.28 days, P = 0.308), with no relapse during 3 months 
      follow up and no significant adverse effect. CP reduced the treatment cost by 33% 
      in comparison to cefixime. Our study suggests CP is effective, safe and cheaper 
      oral option for treatment of typhoid fever in children.
FAU - Shakur, Md Salim
AU  - Shakur MS
AD  - Dhaka Shishu (Children) Hospital, ShereBangla Nagar, Dhaka 1207, Bangladesh. 
      njshantu@yahoo.com
FAU - Arzuman, Selina Akhter Laila
AU  - Arzuman SA
FAU - Hossain, Jesmin
AU  - Hossain J
FAU - Mehdi, Hasan
AU  - Mehdi H
FAU - Ahmed, Mesbahuddin
AU  - Ahmed M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
RN  - 0 (Anti-Bacterial Agents)
RN  - 97I1C92E55 (Cefixime)
RN  - C43C467DPE (Ceftizoxime)
SB  - IM
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Cefixime/*therapeutic use
MH  - Ceftizoxime/*analogs & derivatives/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Typhoid Fever/*drug therapy
MH  - Cefpodoxime Proxetil
EDAT- 2007/12/07 09:00
MHDA- 2010/02/23 06:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PST - ppublish
SO  - Indian Pediatr. 2007 Nov;44(11):838-41.