PMID- 18057558
OWN - NLM
STAT- MEDLINE
DCOM- 20080319
LR  - 20220331
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 12
IP  - 3
DP  - 2007 Nov
TI  - Serotonin transporter gene polymorphism and BPSD in mild Alzheimer's disease.
PG  - 245-53
AB  - The purpose of the present study was to confirm an association of functional 
      polymorphism within the serotonin transporter (5-HTT) gene with Alzheimer's 
      disease (AD) and behavioral and psychological symptoms of dementia (BPSD) in mild 
      AD. Apolipoprotein E (ApoE) gene polymorphism and 2 types of functional 
      polymorphism in the 5-HTT gene, 5-HTT-linked polymorphic region (5-HTTLPR) and a 
      5-HTT variable number of tandem repeats sequence (5-HTTVNTR) were analyzed 
      longitudinally in outpatients with mild AD to find out whether there was a 
      relation between any such polymorphisms and the occurrence of BPSD. No 
      significant differences in genotype distribution or allele frequencies were 
      identified for 5-HTTLPR or 5-HTTVNTR between AD patients and age- and sex-matched 
      non-demented controls regardless of ApoE epsilon4 allele. No significant 
      differences were noted in 5-HTTLPR genotype or allele distributions between AD 
      patients with or without BPSD. However, significant associations were observed 
      between presence of 5-HTTVNTR allele 10 and BPSD or aggressiveness. This 
      difference was independent of the presence of the ApoE epsilon4 allele. As a 
      result, 5-HTT polymorphisms are unlikely to play any substantial role in 
      susceptibility to AD. Conversely, 5-HTTVNTR influences the risk of developing 
      BPSD or aggressiveness and genetic variations in the 5-HTT gene may be involved 
      in the development of symptomatology for mild AD.
FAU - Ueki, Akinori
AU  - Ueki A
AD  - Department of Neuropsychiatry, Hyogo College of Medicine, Nishinomiya, Hyogo, 
      Japan. aki@hyo-med.ac.jp
FAU - Ueno, Hideo
AU  - Ueno H
FAU - Sato, Noriko
AU  - Sato N
FAU - Shinjo, Hidetaka
AU  - Shinjo H
FAU - Morita, Yoshio
AU  - Morita Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoproteins E)
RN  - 0 (DNA Primers)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Aged
MH  - Aggression/psychology
MH  - Alzheimer Disease/epidemiology/*genetics/*metabolism
MH  - Apolipoproteins E/metabolism
MH  - Cognition Disorders/diagnosis/epidemiology
MH  - DNA Primers/genetics
MH  - Dementia/epidemiology/*genetics/*psychology
MH  - Female
MH  - Gene Expression/*genetics
MH  - Genome/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Psychomotor Agitation/epidemiology/*psychology
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
EDAT- 2007/12/07 09:00
MHDA- 2008/03/20 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/03/20 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 10.3233/jad-2007-12306 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2007 Nov;12(3):245-53. doi: 10.3233/jad-2007-12306.