PMID- 18057750
OWN - NLM
STAT- MEDLINE
DCOM- 20080128
LR  - 20190706
IS  - 0009-2363 (Print)
IS  - 0009-2363 (Linking)
VI  - 55
IP  - 12
DP  - 2007 Dec
TI  - Synthesis and HIV-1 integrase inhibition of novel bis- or tetra-coumarin 
      analogues.
PG  - 1740-3
AB  - Present studies were undertaken on the preparation of synthetic analogues of bis- 
      or tetra-coumarins and their activity against HIV-1 integrase (HIV-1 IN). Among 
      these coumarin analogues, compounds 14, 16 and 18 were found to be potent 
      molecules against HIV-1 IN at IC50 values of 0.96, 0.58, and 0.49 microM, 
      respectively. The results provided a tool for guiding the further design of more 
      potent antiviral agents and for predicting the affinity of related compounds.
FAU - Chiang, Chih-Chia
AU  - Chiang CC
AD  - Department of Applied Chemistry and Materials Science, Institute of Technology, 
      National Defense University, Ta-shi, Tao-yuan, Taiwan, ROC..
FAU - Mouscadet, Jean-Francois
AU  - Mouscadet JF
FAU - Tsai, Hou-Jen
AU  - Tsai HJ
FAU - Liu, Chi-Tsan
AU  - Liu CT
FAU - Hsu, Ling-Yih
AU  - Hsu LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Coumarins)
RN  - 0 (HIV Integrase Inhibitors)
RN  - 0 (Oligonucleotides)
RN  - EC 2.7.7.- (HIV Integrase)
SB  - IM
MH  - Chemical Phenomena
MH  - Chemistry, Physical
MH  - Coumarins/*chemical synthesis/*pharmacology
MH  - HIV Integrase/metabolism
MH  - HIV Integrase Inhibitors/*chemical synthesis/*pharmacology
MH  - HIV-1/*drug effects/*enzymology
MH  - Magnetic Resonance Spectroscopy
MH  - Mass Spectrometry
MH  - Oligonucleotides/chemical synthesis/pharmacology
MH  - Spectrophotometry, Infrared
EDAT- 2007/12/07 09:00
MHDA- 2008/01/29 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/01/29 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - JST.JSTAGE/cpb/55.1740 [pii]
AID - 10.1248/cpb.55.1740 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1740-3. doi: 10.1248/cpb.55.1740.