PMID- 18057869
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20211020
IS  - 1421-9670 (Electronic)
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 28
IP  - 3
DP  - 2008
TI  - Kidney volume associations with subclinical renal and cardiovascular disease: the 
      Diabetes Heart Study.
PG  - 366-71
AB  - BACKGROUND: The prognostic significance of total kidney volume (TKV) in subjects 
      with type 2 diabetes mellitus (T2DM) is unknown. METHODS: One hundred and seventy 
      unrelated Caucasians with T2DM underwent multidetector-row computed tomography of 
      the neck, chest, and abdomen to measure calcified plaque in the coronary artery 
      (CorCP), carotid artery (CarCP), and infrarenal aorta (AorCP). Spearman's rank 
      correlation coefficients were used to assess associations between TKV and 
      subclinical renal and cardiovascular disease. Partial correlation coefficients 
      were computed to adjust for the potential confounding effects of age, sex, body 
      mass index, glomerular filtration rate (GFR), diabetes duration, and hemoglobin 
      A(1c). Values are expressed as mean +/- SD (median in parentheses). RESULTS: The 
      study group (51% female) had a mean age of 62.9 +/- 8.5 (62.3) years, a T2DM 
      duration of 11.5 +/- 6.8 (10.0) years, a urinary albumin:creatinine ratio of 
      109.9 +/- 396 (17.6) mg/g, a GFR of 63.8 +/- 12.8 (63.2) ml/min, a TKV of 272.4 
      +/- 69.7 (261.9) cm(3), CorCP 2,170 +/- 3,394 (653), CarCP 374 +/- 673 (104), 
      AorCP 14,569 +/- 17,480 (8,370), and a carotid artery intima-media thickness of 
      0.70 +/- 0.14 (0.68) mm. Adjusting for age, sex, body mass index, diabetes 
      duration, GFR, and hemoglobin A(1c), the TKV was significantly associated with 
      AorCP (r = 0.20, p = 0.016), but not with CorCP, CarCP, or carotid artery 
      intima-media thickness (all p >or= 0.25). No significant associations were 
      detected between TKV and blood pressure or albuminuria. CONCLUSIONS: In 
      Caucasians with T2DM, TKV and calcified atherosclerotic plaque in the infrarenal 
      abdominal aorta are positively associated. Common mechanisms linking renal matrix 
      deposition with aortic atherosclerosis may underlie this association and require 
      further study.
CI  - (c) 2007 S. Karger AG, Basel.
FAU - Saran, Anita M
AU  - Saran AM
AD  - Department of Internal Medicine/Nephrology, Wake Forest University School of 
      Medicine, Winston-Salem, NC 27157-1053, USA. asaran@wfubmc.edu
FAU - Hsu, Fang-Chi
AU  - Hsu FC
FAU - Lohman, Kurt K
AU  - Lohman KK
FAU - Carr, J Jeffrey
AU  - Carr JJ
FAU - Bowden, Donald W
AU  - Bowden DW
FAU - Wagenknecht, Lynne E
AU  - Wagenknecht LE
FAU - Freedman, Barry I
AU  - Freedman BI
LA  - eng
GR  - R01 HL67348/HL/NHLBI NIH HHS/United States
GR  - R01 AR048797/AR/NIAMS NIH HHS/United States
GR  - MO1 RR07122/RR/NCRR NIH HHS/United States
GR  - M01 RR007122-150204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-02/AR/NIAMS NIH HHS/United States
GR  - R01 HL067348/HL/NHLBI NIH HHS/United States
GR  - R01 AR048797-01/AR/NIAMS NIH HHS/United States
GR  - M01 RR007122/RR/NCRR NIH HHS/United States
GR  - R01 AR48797/AR/NIAMS NIH HHS/United States
GR  - M01 RR007122-140204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-03/AR/NIAMS NIH HHS/United States
GR  - M01 RR007122-130204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-04/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071205
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
SB  - IM
MH  - Aged
MH  - Albuminuria/*pathology
MH  - Aorta, Abdominal/diagnostic imaging/pathology
MH  - Atherosclerosis/*diagnostic imaging/pathology
MH  - Blood Pressure/*physiology
MH  - Diabetes Mellitus, Type 2/complications/*diagnosis/physiopathology
MH  - Diabetic Angiopathies/diagnostic imaging/pathology
MH  - Diabetic Neuropathies/diagnostic imaging/pathology
MH  - Female
MH  - Humans
MH  - Kidney/*diagnostic imaging/pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Tomography, X-Ray Computed
PMC - PMC2820343
EDAT- 2007/12/07 09:00
MHDA- 2008/06/24 09:00
PMCR- 2007/12/05
CRDT- 2007/12/07 09:00
PHST- 2007/08/13 00:00 [received]
PHST- 2007/10/18 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PHST- 2007/12/05 00:00 [pmc-release]
AID - 000112226 [pii]
AID - ajn0028-0366 [pii]
AID - 10.1159/000112226 [doi]
PST - ppublish
SO  - Am J Nephrol. 2008;28(3):366-71. doi: 10.1159/000112226. Epub 2007 Dec 5.