PMID- 18058264
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20211020
IS  - 1046-3976 (Print)
IS  - 1046-3976 (Linking)
VI  - 18
IP  - 3
DP  - 2007 Fall
TI  - Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors.
PG  - 150-5
AB  - This review focuses on precursor lesions of gastrointestinal and pancreatic 
      neuroendocrine tumors (GEP-NETs). There are three conditions that are associated 
      with hyperplastic changes in endocrine cells preceding GEP-NETs: autoimmune 
      chronic atrophic gastritis or multiple endocrine neoplasia type 1 (MEN1) with 
      gastric enterochromaffin-like (ECL) cell hyperplasia; MEN1 with gastrin and 
      somatostatin cell hyperplasia in the duodenum and glucagon cell hyperplasia in 
      the islets of the pancreas; and inflammatory bowel disease with endocrine cell 
      hyperplasia in the colon. In gastric ECL cell hyperplasia, it is assumed that 
      hypergastrinemia promotes the growth of the ECL cells of the corpus mucosa and 
      leads to hyperplasia and neoplasia. In the duodenum and the pancreas, the 
      MEN1-associated germline mutation of the menin gene obviously causes hyperplasia 
      of the gastrin and somatostatin cells (duodenum) and the glucagon cells 
      (pancreas), resulting in multifocal development of tumors. These tumors show 
      allelic deletion of the MEN1 gene, whereas the precursor lesions retain their 
      heterozygosity. The endocrine cell hyperplasia in the colon described in 
      inflammatory bowel disease has neither a genetic nor a definite hormonal 
      background.
FAU - Kloppel, Gunter
AU  - Kloppel G
AD  - Department of Pathology, University of Kiel, Michaelisstr. 11, 24105, Kiel, 
      Germany. guenterkloeppel@path.uni-kiel.de
FAU - Anlauf, Martin
AU  - Anlauf M
FAU - Perren, Aurel
AU  - Perren A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Endocr Pathol
JT  - Endocrine pathology
JID - 9009288
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Colonic Neoplasms/genetics/metabolism/pathology
MH  - Duodenal Neoplasms/genetics/metabolism/pathology
MH  - Gastrointestinal Neoplasms/genetics/metabolism/*pathology
MH  - Humans
MH  - Models, Biological
MH  - Neuroendocrine Tumors/genetics/metabolism/*pathology
MH  - Pancreatic Neoplasms/genetics/metabolism/*pathology
MH  - Precancerous Conditions/*etiology/genetics/metabolism
MH  - Rectal Neoplasms/genetics/metabolism/pathology
MH  - Stomach Neoplasms/genetics/metabolism/pathology
RF  - 32
EDAT- 2007/12/07 09:00
MHDA- 2008/02/26 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 10.1007/s12022-007-0025-5 [doi]
PST - ppublish
SO  - Endocr Pathol. 2007 Fall;18(3):150-5. doi: 10.1007/s12022-007-0025-5.