PMID- 18059153
OWN - NLM
STAT- MEDLINE
DCOM- 20080204
LR  - 20201209
IS  - 0021-4884 (Print)
IS  - 0021-4884 (Linking)
VI  - 56
IP  - 11
DP  - 2007 Nov
TI  - [Case of allergic bronchopulmonary aspergillosis successfully treated with 
      itraconazole].
PG  - 1390-6
AB  - A 58-year-old woman had a productive cough but not from bronchial asthma. A chest 
      radiograph revealed infiltrative shadows in right middlelung field on September, 
      2004. Aspergillus fumigatus was detected in a sputum culture. She was treated 
      with oral itraconazole. After the treatment, infiltrative shadows on her chest 
      radiograph disappeared. On October 2005, her peripheral blood showed 
      eosinophilla, a high serum level of total immunoglobulin E (IgE), and a chest 
      radiograph revealed new infiltrative shadows in both lung fields. A chest 
      computed tomography revealed multiple nodular shadows and central bronchiectasis. 
      We detected a mucoid plug which showed a large number of eosinophils 
      pathologically by bronchoscopy. Aspergillus niger was detected in a bronchial 
      lavage fluid. We therefore made a diagnosis of allergic bronchopulmonary 
      aspergillosis (ABPA). The decreases of peripheral blood eosinophils and a serum 
      IgE level were recognized and multiple nodular shadows disappeared by 
      reinstitution of itraconazole. However, a chest computed tomography revealed new 
      infiltrative shadows. Therefore, we treated her with the concomitant 
      administration of oral itraconazole and inhaled corticosteroid. All laboratory 
      data and image findings were improved. It is critical to consider the both 
      aspects of allergy and infection in the treatment for ABPA.
FAU - Isobe, Zen
AU  - Isobe Z
AD  - Department of Respiratory Medicine, Gunma University Graduate School of Medicine. 
      isobezen@showa.gunma-u.ac.jp
FAU - Suga, Tatsuo
AU  - Suga T
FAU - Hamaguchi, Shigeto
AU  - Hamaguchi S
FAU - Hara, Kenichirou
AU  - Hara K
FAU - Aoki, Nozomi
AU  - Aoki N
FAU - Aoki, Fumiaki
AU  - Aoki F
FAU - Aoyagi, Kana
AU  - Aoyagi K
FAU - Ueno, Manabu
AU  - Ueno M
FAU - Maeno, Toshitaka
AU  - Maeno T
FAU - Kurabayashi, Masahiko
AU  - Kurabayashi M
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Arerugi
JT  - Arerugi = [Allergy]
JID - 0241212
RN  - 0 (Androstadienes)
RN  - 0 (Antifungal Agents)
RN  - 304NUG5GF4 (Itraconazole)
RN  - CUT2W21N7U (Fluticasone)
SB  - IM
MH  - Administration, Inhalation
MH  - Androstadienes/administration & dosage
MH  - Antifungal Agents/*administration & dosage/*therapeutic use
MH  - Aspergillosis, Allergic Bronchopulmonary/diagnosis/*drug therapy/microbiology
MH  - Aspergillus fumigatus/isolation & purification
MH  - Aspergillus niger/isolation & purification
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fluticasone
MH  - Humans
MH  - Itraconazole/*administration & dosage
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2007/12/07 09:00
MHDA- 2008/02/05 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/04/24 00:00 [received]
PHST- 2007/07/03 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/02/05 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 056111390e [pii]
PST - ppublish
SO  - Arerugi. 2007 Nov;56(11):1390-6.