PMID- 18059328
OWN - NLM
STAT- MEDLINE
DCOM- 20080428
LR  - 20211020
IS  - 0007-1188 (Print)
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Linking)
VI  - 153 Suppl 1
IP  - Suppl 1
DP  - 2008 Mar
TI  - Role of the brain-derived neurotrophic factor at glutamatergic synapses.
PG  - S310-24
AB  - The neurotrophin brain-derived neurotrophic factor (BDNF) plays an important role 
      in the activity-dependent regulation of synaptic structure and function, 
      particularly of the glutamatergic synapses. BDNF may be released in the mature 
      form, which activates preferentially TrkB receptors, or as proBDNF, which is 
      coupled to the stimulation of the p75(NTR). In the mature form BDNF induces rapid 
      effects on glutamate release, and may induce short- and long-term effects on the 
      postsynaptic response to the neurotransmitter. BDNF may affect glutamate receptor 
      activity by inducing the phosphorylation of the receptor subunits, which may also 
      affect the interaction with intracellular proteins and, consequently, their 
      recycling and localization to defined postsynaptic sites. Stimulation of the 
      local protein synthesis and transcription activity account for the delayed 
      effects of BDNF on glutamatergic synaptic strength. Several evidences show 
      impaired synaptic plasticity of glutamatergic synapses in diseases where 
      compromised BDNF function has been observed, such as Huntington's disease, 
      depression, anxiety, and the BDNF polymorphism Val66Met, suggesting that 
      upregulating BDNF-activated pathways may be therapeutically relevant. This review 
      focuses on recent advances in the understanding of the regulation of the 
      glutamatergic synapse by BDNF, and its implications in synaptic plasticity.
FAU - Carvalho, A L
AU  - Carvalho AL
AD  - Center for Neuroscience and Cell Biology, Department of Zoology, University of 
      Coimbra, Coimbra, Portugal. alc@ibili.uc.pt
FAU - Caldeira, M V
AU  - Caldeira MV
FAU - Santos, S D
AU  - Santos SD
FAU - Duarte, C B
AU  - Duarte CB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071203
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Glutamic Acid/*physiology
MH  - Humans
MH  - Neuronal Plasticity/physiology
MH  - Receptor, Nerve Growth Factor/physiology
MH  - Receptor, trkB/physiology
MH  - Signal Transduction/physiology
MH  - Subcellular Fractions/metabolism
MH  - Synapses/metabolism/*physiology
PMC - PMC2268077
EDAT- 2007/12/07 09:00
MHDA- 2008/04/29 09:00
PMCR- 2009/03/01
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/04/29 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - 0707509 [pii]
AID - 10.1038/sj.bjp.0707509 [doi]
PST - ppublish
SO  - Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S310-24. doi: 
      10.1038/sj.bjp.0707509. Epub 2007 Dec 3.