PMID- 18059655
OWN - NLM
STAT- MEDLINE
DCOM- 20080211
LR  - 20120910
IS  - 0048-0169 (Print)
IS  - 0048-0169 (Linking)
VI  - 55
IP  - 6
DP  - 2007 Dec
TI  - Descriptive summary of an outbreak of porcine post-weaning multisystemic wasting 
      syndrome (PMWS ) in New Zealand.
PG  - 346-52
AB  - CASE HISTORY: Investigations were conducted to determine the cause of an acute, 
      multi-farm outbreak of porcine respiratory disease that included diarrhoea and 
      subsequent loss of body condition in affected pigs. A definition for post-weaning 
      multisystemic wasting syndrome (PMWS) including both clinical and pathological 
      features, previously developed for the pig industry in New Zealand, was applied 
      to the current outbreak. In addition to self-reporting by owners of affected 
      farms, local veterinarians, disease and epidemiology consultants, and animal 
      health officials from the Ministry of Agriculture and Forestry (MAF) were 
      involved in conducting farm visits and submission of diagnostic specimens. 
      CLINICAL FINDINGS AND DIAGNOSIS: Pathogens known to be endemic in the pig 
      industry in New Zealand as well as likely exotic diseases were excluded as 
      causative agents of the outbreak. Clinical signs including dyspnoea, diarrhoea, 
      and rapid loss of body condition were consistent with the New Zealand case 
      definition for PMWS. Interstitial pneumonia, pulmonary oedema, generalised 
      lymph-node enlargement, and presence of porcine circovirus type 2 (PCV2) 
      inclusion bodies were consistently identified in affected pigs. Classical swine 
      fever virus (CSFv), Porcine reproductive and respiratory syndrome virus (PRRSv), 
      and Influenza virus were ruled out, using molecular and traditional virological 
      techniques. Spread of the disease between farms was hypothesised to be 
      facilitated by locally migrating flocks of black-backed seagulls. The original 
      source of the disease incursion was not identified. DIAGNOSIS: Based on the 
      consistent presence of circovirus-associated lesions in lymphoid tissues in 
      combination with generalised enlargement of lymph nodes, histiocytic interstitial 
      pneumonia, clinical wasting, and poor response to antibiotic therapy, a diagnosis 
      of PMWS was made. CLINICAL RELEVANCE: PMWS should be considered in the 
      differential diagnoses of sudden onset of respiratory dyspnoea, diarrhoea, and 
      rapid loss of body condition in young pigs in New Zealand pig herds.
FAU - Neumann, E J
AU  - Neumann EJ
AD  - EpiCentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey 
      University, Private Bag 11222, Palmerston North, New Zealand. 
      e.neumann@massey.ac.nz
FAU - Dobbinson, S S A
AU  - Dobbinson SS
FAU - Welch, E B M
AU  - Welch EB
FAU - Morris, R S
AU  - Morris RS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - N Z Vet J
JT  - New Zealand veterinary journal
JID - 0021406
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Circoviridae Infections/diagnosis/epidemiology/*veterinary
MH  - Circovirus/*isolation & purification
MH  - Diagnosis, Differential
MH  - Disease Outbreaks/*veterinary
MH  - New Zealand
MH  - Swine
MH  - Swine Diseases/diagnosis/*epidemiology
MH  - Wasting Syndrome/diagnosis/epidemiology/*veterinary
MH  - Weaning
EDAT- 2007/12/07 09:00
MHDA- 2008/02/12 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/02/12 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 10.1080/00480169.2007.36792 [doi]
PST - ppublish
SO  - N Z Vet J. 2007 Dec;55(6):346-52. doi: 10.1080/00480169.2007.36792.