PMID- 18060211
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20220311
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 28
IP  - 12
DP  - 2007 Dec
TI  - Infliximab "TNF-alpha antagonist" decreases intraabdominal adhesions.
PG  - 1830-5
AB  - OBJECTIVE: To evaluate the effect of infliximab on adhesion formation and it's 
      associated morbidity and complications. METHODS: This study was performed in the 
      Faculty of Medicine, Gazi University, Turkey between July 2005 and October 2005. 
      Thirty-five rats were randomly divided into 4 groups. Laparotomy was performed in 
      the Sham group (n=5), whereas cecal abrasion was carried out in all other groups. 
      After cecal abrasion 0.9% sodium chloride was administered in the saline group 
      (n=10), infliximab was administered to the study group (n=10) and nothing was 
      administered to the last group (n=10). Adhesion formation was evaluated with 
      macroscopic and microscopic adhesion scoring systems. Peritoneal fluid samples 
      and mesenteric lymph node biopsies were taken to rule out bacterial peritonitis. 
      Blood and peritoneal irrigation fluid samples were taken to measure the Tumor 
      necrosis factor-alpha (TNF-alpha) levels. RESULTS: Macroscopic adhesion scores 
      showed fewer adhesions in the infliximab group. The infliximab group had 
      significantly fewer adhesions than the abrasion control and saline groups. 
      According to the histological findings, there were no statistically significant 
      differences between the groups. CONCLUSION: Early blocking of the activity of 
      TNF-alpha after cecal abrasion resulted in lower rates of adhesion formation, 
      macroscopically. The TNF-alpha, a proinflammatory cytokine appears to be an 
      important mediator for postoperative adhesion formation.
FAU - Kurukahvecioglu, Osman
AU  - Kurukahvecioglu O
AD  - Faculty of Medicine, Gazi Universitesi Tip Fakultesi, Genel Cerrahi Anabilim Dali 
      Besevler, Ankara, Turkey. okurukahveci@yahoo.com
FAU - Koksal, Hande
AU  - Koksal H
FAU - Gulbahar, Ozlem
AU  - Gulbahar O
FAU - Erdem, Ozlem
AU  - Erdem O
FAU - Engin, Doruk
AU  - Engin D
FAU - Yazicioglu, Omer
AU  - Yazicioglu O
FAU - Kerem, Mustafa
AU  - Kerem M
FAU - Taneri, Ferit
AU  - Taneri F
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
SB  - IM
MH  - Abdominal Wall/pathology/*surgery
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Infliximab
MH  - Male
MH  - Peritoneal Diseases/etiology/*prevention & control
MH  - *Postoperative Complications
MH  - Rats
MH  - Rats, Wistar
MH  - Tissue Adhesions/etiology/prevention & control
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
EDAT- 2007/12/07 09:00
MHDA- 2008/03/28 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 20070377' [pii]
PST - ppublish
SO  - Saudi Med J. 2007 Dec;28(12):1830-5.