PMID- 18060363
OWN - NLM
STAT- MEDLINE
DCOM- 20080521
LR  - 20211020
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 87
IP  - 1
DP  - 2008 Mar
TI  - Implicating chromosomal aberrations with meningioma growth and recurrence: 
      results from FISH and MIB-I analysis of grades I and II meningioma tissue.
PG  - 43-50
AB  - The fluorescence in situ hybridization (FISH) technique was used in 111 WHO 
      grades I and II meningioma patients. Clinical, radiological, pathological, and 
      immunohistochemical data were compared to aberrations of chromosomes 1p, 14q, and 
      22q determined by FISH. Significant differences for MIB-1 labeling were found 
      between grades I and II tumors (p < 0.001), and between grade I tumors that 
      recurred and those that did not recur (p < 0.001). Chromosomal aberrations were 
      detected with FISH analysis in nearly 50% of grade I, and in 93% of grade II 
      meningiomas. The numbers of chromosomal aberrations correlated significantly to 
      MIB-1 (p < 0.001), with signs of grossly invasive tumor growth (p < 0.001), and 
      with tumor recurrence (p < 0.01). The findings suggest that adding FISH analysis 
      may allow better prediction of possible meningioma recurrence and may be a useful 
      adjunct for therapy decisions.
FAU - Pfisterer, Wolfgang K
AU  - Pfisterer WK
AD  - Neurosurgery Research, Barrow Neurological Institute, St. Joseph's Hospital and 
      Medical Center, Phoenix, AZ 85013, USA. wolfgang.pfisterer@wienkav.at
FAU - Coons, Stephen W
AU  - Coons SW
FAU - Aboul-Enein, Fahmy
AU  - Aboul-Enein F
FAU - Hendricks, William P
AU  - Hendricks WP
FAU - Scheck, Adrienne C
AU  - Scheck AC
FAU - Preul, Mark C
AU  - Preul MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071130
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Proliferation
MH  - *Chromosome Aberrations
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Ki-67 Antigen/*metabolism
MH  - Meningeal Neoplasms/*genetics/metabolism/pathology
MH  - Meningioma/*genetics/metabolism/pathology
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/metabolism/*pathology
MH  - Prognosis
EDAT- 2007/12/07 09:00
MHDA- 2008/05/22 09:00
CRDT- 2007/12/07 09:00
PHST- 2007/06/07 00:00 [received]
PHST- 2007/11/20 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/05/22 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
AID - 10.1007/s11060-007-9498-9 [doi]
PST - ppublish
SO  - J Neurooncol. 2008 Mar;87(1):43-50. doi: 10.1007/s11060-007-9498-9. Epub 2007 Nov 
      30.