PMID- 18060853
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20211020
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 366
IP  - 1
DP  - 2008 Feb 1
TI  - Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I.
PG  - 104-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that may contribute to the 
      pathogenesis of septic shock, rheumatoid arthritis, cancer, and diabetes. 
      Prostaglandins endogenously produced by macrophages act in an autocrine fashion 
      to limit TNF-alpha production. We investigated the timing and signaling pathway 
      of prostaglandin-mediated inhibition of TNF-alpha production in Raw 264.7 and 
      J774 macrophages. TNF-alpha mRNA levels were rapidly modulated by PGE(2) or 
      carbaprostacylin. PGE(2) or carbaprostacyclin prevented and rapidly terminated 
      on-going TNF-alpha gene transcription within 15 min of prostaglandin treatment. 
      Selective activation of PKA type I, but not PKA type II or Epac, with chemical 
      analogs of cAMP was sufficient to inhibit LPS-induced TNF-alpha mRNA levels. The 
      mechanisms by which prostaglandins limit TNF-alpha mRNA levels may underlie 
      endogenous regulatory mechanisms that limit inflammation, and may have important 
      implications for understanding chronic inflammatory disease pathogenesis.
FAU - Stafford, Jennifer B
AU  - Stafford JB
AD  - Department of Biochemistry, Vanderbilt University School of Medicine, 23rd Avenue 
      South at Pierce, Nashville, TN 37232-0146, USA.
FAU - Marnett, Lawrence J
AU  - Marnett LJ
LA  - eng
GR  - P01 GM015431/GM/NIGMS NIH HHS/United States
GR  - P50 GM015431/GM/NIGMS NIH HHS/United States
GR  - P50 GM015431-410001/GM/NIGMS NIH HHS/United States
GR  - GM015431/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071203
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 63231-63-0 (RNA)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinase Type I)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cyclic AMP-Dependent Protein Kinase Type I/*metabolism
MH  - Dinoprostone/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Macrophages/drug effects/*metabolism
MH  - Mice
MH  - RNA/metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
PMC - PMC2761429
MID - NIHMS37230
EDAT- 2007/12/07 09:00
MHDA- 2008/02/06 09:00
PMCR- 2009/10/13
CRDT- 2007/12/07 09:00
PHST- 2007/11/16 00:00 [received]
PHST- 2007/11/19 00:00 [accepted]
PHST- 2007/12/07 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/12/07 09:00 [entrez]
PHST- 2009/10/13 00:00 [pmc-release]
AID - S0006-291X(07)02509-0 [pii]
AID - 10.1016/j.bbrc.2007.11.091 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2008 Feb 1;366(1):104-9. doi: 
      10.1016/j.bbrc.2007.11.091. Epub 2007 Dec 3.