PMID- 18062171
OWN - NLM
STAT- MEDLINE
DCOM- 20080103
LR  - 20220318
IS  - 2072-0939 (Print)
IS  - 2072-0939 (Linking)
VI  - 30
IP  - 5
DP  - 2007 Sep-Oct
TI  - Associations between brain-derived neurotrophic factor G196A gene polymorphism 
      and clinical phenotypes in schizophrenia patients.
PG  - 408-13
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) had been chosen as a 
      candidate gene for schizophrenia. This study investigated the relationships 
      between BDNF G196A gene polymorphism and clinical phenotypes in schizophrenia 
      patients in the Taiwanese population. METHODS: During a one year period, 132 
      schizophrenic patients and 103 healthy controls were recruited. Psychiatric 
      diagnoses were made according to DSM-IV criteria. Genotyping of the G196A 
      polymorphism of BDNF was performed by polymerase chain reaction amplification and 
      restriction fragment length polymorphism. RESULTS: The data showed that the BDNF 
      G196A genotypes and their allele distributions did not differ between patients 
      with schizophrenia and healthy controls. No significant differences were noted in 
      the BDNF G196A genotypes and allele distribution between schizophrenia patients 
      with and without a family tendency for schizophrenia or between those with an age 
      of onset before or after 25 years old. However, there was a significant 
      difference in BDNF G196A genotype distribution between schizophrenia patients 
      with and without a suicide history. CONCLUSIONS: These analytical results suggest 
      that BDNF G196A gene polymorphism is associated with a susceptibility to a 
      suicide history in schizophrenia patients in the Taiwanese population. Further 
      study with a larger number of samples is needed to prove these findings.
FAU - Huang, Tiao-Lai
AU  - Huang TL
AD  - Department of Psychiatry, Chang Gung Memorial Hospital, Chang Gung University 
      College of Medicine, Kaohsiung, Taiwan. a540520@cgmh.org.tw
FAU - Lee, Chien-Te
AU  - Lee CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Chang Gung Med J
JT  - Chang Gung medical journal
JID - 101088034
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Schizophrenia/*genetics
MH  - Suicide
EDAT- 2007/12/08 09:00
MHDA- 2008/01/04 09:00
CRDT- 2007/12/08 09:00
PHST- 2007/12/08 09:00 [pubmed]
PHST- 2008/01/04 09:00 [medline]
PHST- 2007/12/08 09:00 [entrez]
AID - 3005/300504 [pii]
PST - ppublish
SO  - Chang Gung Med J. 2007 Sep-Oct;30(5):408-13.