PMID- 18062284
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20071207
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 21
IP  - 18
DP  - 2007 Sep
TI  - [The changes and significance of microsatellite loss of heterozygosity in 
      laryngeal premalignant lesions and squamous cell carcinoma].
PG  - 831-3
AB  - OBJECTIVE: To evaluate the character and significance of the loss of 
      heterozygosity (LOH) on chromosomes 3P, 9P and 17P in laryngeal premalignant and 
      malignant lesions. METHOD: Allelic deletions analysis was performed with 6 
      polymorphic markers (D3S1234, D9S171, D9S1748, D9S162, INFA and p53) using 
      polymerase chain reaction-single sequence length polymorphism-silver staining in 
      49 laryngeal premalignant and malignant lesions. RESULT: Allelic loss was seen in 
      3.70% of the six markers in patients with simple hyperplasias (HP), 10.81% with 
      low grade dysplasia (LGD), 26.03% with high grade dysplasia (HGD) and 38.67% with 
      laryngeal squamous cell carcinoma (LSCC). Significant differences was found 
      between allelic loss and clinical pathological grades (X2 = 17.686, P < 0.01). 
      The rate of LOH increased remarkably with the lesions progressed from HP to LSCC. 
      D9S171showed the highest incidence of LOH (35.00%) on the six markers. 
      CONCLUSION: Microsatellite DNA LOHs occur in early stage of laryngeal 
      carcinogenesis. Microsatellite markers may be useful in the early diagnosis for 
      laryngeal premalignant lesions.
FAU - Guo, Tao
AU  - Guo T
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, the Affiliated Province 
      Hospital, Anhui Medical University, Hefei, 230001, China.
FAU - Sun, Jingwu
AU  - Sun J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Precancerous Conditions/*genetics/pathology
EDAT- 2007/12/08 09:00
MHDA- 2011/06/10 06:00
CRDT- 2007/12/08 09:00
PHST- 2007/12/08 09:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PHST- 2007/12/08 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Sep;21(18):831-3.