PMID- 18063051 OWN - NLM STAT- MEDLINE DCOM- 20080502 LR - 20161124 IS - 0161-813X (Print) IS - 0161-813X (Linking) VI - 29 IP - 1 DP - 2008 Jan TI - Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. PG - 160-9 AB - Perfluorinated compounds (PFCs) are found in applications such oil/water repellents for clothing fabrics, carpets, food packaging, lubricants, surfactants and fire extinguishers. PFCs are persistent in the environment. They have been found in humans and in wildlife. We reported earlier that persistent organic pollutants (POPs), such as DDT, PCBs and BFRs, caused developmental neurotoxic defects in mice, manifested as persistent aberrations in spontaneous behaviour, habituation capability, learning and memory, and changes in the cholinergic system in adults, when mice were exposed during a critical period of neonatal brain development. The present study was conducted to see whether PFCs can cause similar developmental neurotoxic effects as earlier observed for POPs as PCBs and PBDEs. NMRI male mice were exposed to a single-oral dose, either 1.4 or 21 micromol/kg body weight of PFOS (0.75 or 11.3 mg), PFOA (0.58 or 8.70 mg), or PFDA (0.72 or 10.8 mg), via a metal gastric-tube at the age of 10 days. The control animals received in the same manner 10 ml/kg body weight of the 20% fat emulsion vehicle. Spontaneous behaviour (locomotion, rearing, and total activity), and habituation were observed in 2- and 4-month-old mice. The susceptibility of the cholinergic system was explored in a nicotine-induced spontaneous behaviour test in 4-month-old mice. Deranged spontaneous behaviour was observed in mice exposed to PFOS and PFOA, manifested as reduced and/or lack of habituation and hyperactivity in adult mice. These effects were also seen to worse with age. Neonatal exposure to PFOS and PFOA affected the cholinergic system, manifested as a hypoactive response to nicotine, compared to a hyperactive response to nicotine in controls. These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants. FAU - Johansson, N AU - Johansson N AD - Department of Environmental Toxicology, Uppsala University, Norbyvagen 18 A, S-752 36 Uppsala, Sweden. FAU - Fredriksson, A AU - Fredriksson A FAU - Eriksson, P AU - Eriksson P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20071101 PL - Netherlands TA - Neurotoxicology JT - Neurotoxicology JID - 7905589 RN - 0 (Alkanesulfonic Acids) RN - 0 (Caprylates) RN - 0 (Fluorocarbons) RN - 0 (Nicotinic Agonists) RN - 6M3C89ZY6R (Nicotine) RN - 947VD76D3L (perfluorooctanoic acid) RN - 9H2MAI21CL (perfluorooctane sulfonic acid) SB - IM MH - *Alkanesulfonic Acids MH - Analysis of Variance MH - Animals MH - Animals, Newborn MH - Behavior, Animal/drug effects MH - Brain Diseases/*chemically induced/physiopathology MH - *Caprylates MH - Disease Models, Animal MH - Dose-Response Relationship, Drug MH - Exploratory Behavior/drug effects MH - Female MH - *Fluorocarbons MH - Locomotion/drug effects MH - Male MH - Maze Learning/drug effects MH - Mental Disorders/*chemically induced/physiopathology MH - Mice MH - Nicotine/pharmacology MH - Nicotinic Agonists/pharmacology MH - Pregnancy MH - Time Factors EDAT- 2007/12/08 09:00 MHDA- 2008/05/03 09:00 CRDT- 2007/12/08 09:00 PHST- 2007/06/28 00:00 [received] PHST- 2007/10/18 00:00 [revised] PHST- 2007/10/24 00:00 [accepted] PHST- 2007/12/08 09:00 [pubmed] PHST- 2008/05/03 09:00 [medline] PHST- 2007/12/08 09:00 [entrez] AID - S0161-813X(07)00240-9 [pii] AID - 10.1016/j.neuro.2007.10.008 [doi] PST - ppublish SO - Neurotoxicology. 2008 Jan;29(1):160-9. doi: 10.1016/j.neuro.2007.10.008. Epub 2007 Nov 1.