PMID- 18063352
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20171116
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 18
IP  - 8
DP  - 2008 Oct
TI  - Body iron stores in relation to the metabolic syndrome, glycemic control and 
      complications in female patients with type 2 diabetes.
PG  - 559-66
AB  - BACKGROUND AND AIM: Studies suggest that iron plays a significant role in the 
      development of diabetes and its complications. This study evaluates the 
      associations of iron metabolism parameters with the metabolic syndrome (MS), 
      control and complications in female patients with type 2 diabetes mellitus 
      (T2DM). METHODS AND RESULTS: Ferritin, soluble Transferrin Receptor (sTfR), 
      sTfR/Log ferritin ratio (sTfR-F index), iron, full blood count and 
      high-sensitivity C-reactive protein (hs-CRP) were determined in 110 female 
      patients with T2DM. Steady state beta cell function (%B), insulin sensitivity 
      (%S) and insulin resistance were assessed with homeostasis model. Patients were 
      divided into tertiles of ferritin and sTfR-F index and according to the presence 
      or absence of the MS and diabetic complications. Patients within the lowest 
      tertile of the sTfR-F index had significantly higher fasting insulin, percent B, 
      low-density lipoprotein cholesterol and Apolipoprotein B than those in the 
      highest tertile. Ferritin showed significant correlations with insulin, percent B 
      and inverse correlations with adiponectin and percent S. The sTfR-F index was 
      significantly correlated with insulin, percent B and lipid parameters. Correcting 
      for hs-CRP abolished the correlations with ferritin but not the sTfR-F index. 
      Higher indices of body iron were significantly associated with diabetes 
      complications but no associations were found with MS, glucose or glycemic 
      control. Multiple regression analysis with confounding variables showed ferritin 
      and the sTfR-F index were not independently associated with diabetes 
      complications. CONCLUSIONS: Association of ferritin with metabolic derangements 
      and complications in diabetes is partly dependent on association with 
      inflammation. Iron status, estimated with the sTfR-F index, is associated with 
      metabolic derangements and complications but the associations are dependent on 
      other risk factors. Prospective studies that use the sTfR-F index as a marker of 
      iron status are required to confirm the role of iron in the etiopathogenesis of 
      T2DM and its complications.
FAU - Mojiminiyi, Olusegun A
AU  - Mojiminiyi OA
AD  - Department of Pathology, Faculty of Medicine, Kuwait University, P.O. Box 24923, 
      Safat 13110, Kuwait. segunade@yahoo.com
FAU - Marouf, Rajaa
AU  - Marouf R
FAU - Abdella, Nabila A
AU  - Abdella NA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071211
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Blood Glucose)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adipose Tissue/anatomy & histology
MH  - Alanine Transaminase/blood
MH  - Alkaline Phosphatase/blood
MH  - Aspartate Aminotransferases/blood
MH  - Bilirubin/blood
MH  - Blood Glucose/*metabolism
MH  - C-Reactive Protein/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications/enzymology/*metabolism
MH  - Female
MH  - Ferritins/blood
MH  - Humans
MH  - Informed Consent
MH  - Iron/*metabolism
MH  - Kuwait
MH  - Menopause
MH  - Metabolic Syndrome/blood/enzymology/*metabolism
EDAT- 2007/12/08 09:00
MHDA- 2009/02/14 09:00
CRDT- 2007/12/08 09:00
PHST- 2007/04/30 00:00 [received]
PHST- 2007/07/13 00:00 [revised]
PHST- 2007/07/26 00:00 [accepted]
PHST- 2007/12/08 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2007/12/08 09:00 [entrez]
AID - S0939-4753(07)00167-6 [pii]
AID - 10.1016/j.numecd.2007.07.007 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2008 Oct;18(8):559-66. doi: 
      10.1016/j.numecd.2007.07.007. Epub 2007 Dec 11.