PMID- 18063934
OWN - NLM
STAT- MEDLINE
DCOM- 20080207
LR  - 20071227
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 28
IP  - 6
DP  - 2007 Dec
TI  - Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in 
      chronic fatigue syndrome (CFS) and major depression: evidence that an 
      IgM-mediated immune response against Pi is one factor underpinning the 
      comorbidity between both CFS and depression.
PG  - 861-7
AB  - Major depression and chronic fatigue syndrome (CFS) are accompanied by signs of 
      oxidative and nitrosative stress (O&NS) and an inflammatory response. 
      Phosphatidyl inositol (Pi) is thought to play a role in depression. The aim of 
      the present study is to examine whether depression and CFS are characterized by 
      an IgM-mediated immune response directed against Pi. Toward this end, this study 
      examines the serum IgM antibodies directed against Pi in 14 patients with major 
      depression, 14 patients with CFS, 14 subjects with partial CFS, and in 11 normal 
      controls. We found that the prevalence and mean value for the serum IgM levels 
      directed against Pi were significantly greater in patients with major depression 
      and CFS than in normal controls and patients with partial CFS. There were 
      significant and positive correlations between serum IgM levels directed against 
      Pi and two symptoms of the FibroFatigue Scale, i.e. fatigue and depression. The 
      results show that an IgM-related immune response directed against Pi may occur in 
      both depression and CFS and may play a role in the pathophysiology of the key 
      symptom of CFS and major depression. It is suggested that the above disorders in 
      Pi result from increased O&NS in both depression and CFS. Autoanti-Pi antibodies 
      may have biological effects, for example, by changing inositol 1,4,5-triphosphate 
      (IP3), phosphatidylinositol-4,5-bisphosphate (PIP2), diacylglycerol and 
      phosphatidylinositol-3,4,5-triphosphate (PIP3) production, thus interfering with 
      intracellular signalling processes. Future research in major depression and CFS 
      should focus on the functional consequences of the immune responses directed 
      against Pi.
FAU - Maes, Michael
AU  - Maes M
AD  - MCare4U Outpatient Clinics, Belgium. crc.mh@telenet.be
FAU - Mihaylova, Ivanka
AU  - Mihaylova I
FAU - Leunis, Jean-Claude
AU  - Leunis JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Immunoglobulin M)
RN  - 0 (Phosphatidylinositols)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Antibody Formation/immunology
MH  - Autoimmunity/*immunology
MH  - Depression/blood/complications/immunology
MH  - Depressive Disorder, Major/blood/complications/*immunology
MH  - Fatigue/blood/complications/immunology
MH  - Fatigue Syndrome, Chronic/blood/complications/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Phosphatidylinositols/*immunology
MH  - Reference Values
MH  - Statistics, Nonparametric
EDAT- 2007/12/08 09:00
MHDA- 2008/02/08 09:00
CRDT- 2007/12/08 09:00
PHST- 2007/10/21 00:00 [received]
PHST- 2007/11/18 00:00 [accepted]
PHST- 2007/12/08 09:00 [pubmed]
PHST- 2008/02/08 09:00 [medline]
PHST- 2007/12/08 09:00 [entrez]
AID - NEL280607A12 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2007 Dec;28(6):861-7.