PMID- 18064508
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20211020
IS  - 0172-0643 (Print)
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 29
IP  - 2
DP  - 2008 Mar
TI  - Polymorphisms of human leukocyte antigen genes in korean children with Kawasaki 
      disease.
PG  - 402-8
AB  - BACKGROUND: Kawasaki disease is a leading cause of acquired heart disease in 
      children. The prevalence rate varies in different ethnic groups. Recently, with 
      the clinical application of molecular genetic technology, human leukocyte antigen 
      (HLA) polymorphisms associated with several diseases have been identified by DNA 
      analysis. This study aimed to assess the association of HLA alleles with 
      susceptibility and complications of Kawasaki disease in Korean children. METHODS: 
      In this study, DNA was extracted from 74 children with a diagnosis of Kawasaki 
      disease. The polymorphisms of the HLA-A, -B, -C, and -DRB1 alleles of patients 
      with Kawasaki disease were determined by polymerase chain reaction 
      (PCR)-amplification refractory mutation system (ARMS) and PCR-sequence-specific 
      primer (SSP) analysis. The polymorphisms identified were compared with those of 
      159 normal healthy control subjects. RESULTS: There was a significant increase in 
      the frequencies of the HLA-B35, -B75, and -Cw09 alleles in patients with Kawasaki 
      disease compared with the healthy control group. There was no increase in the 
      frequency of HLA-DRB1 alleles among the Kawasaki disease patients compared with a 
      healthy control group. When the patients with Kawasaki disease were divided into 
      two subgroups, with or without coronary complications, the Kawasaki disease 
      patients with coronary complications showed a significantly increased frequency 
      of the HLA-DRB1*11 allele compared with the healthy control group and increased 
      frequency of HLA-DRB1*09 in a comparison of the subgroups. CONCLUSIONS: This 
      study suggests that polymorphisms in some alleles of B and C in HLA class I genes 
      are associated with Kawasaki disease in Korean children.
FAU - Oh, Jin Hee
AU  - Oh JH
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul, Republic of Korea.
FAU - Han, Ji Whan
AU  - Han JW
FAU - Lee, Soon Ju
AU  - Lee SJ
FAU - Lee, Kyung Yil
AU  - Lee KY
FAU - Suh, Byung Kyu
AU  - Suh BK
FAU - Koh, Dae Kyun
AU  - Koh DK
FAU - Lee, Joon Sung
AU  - Lee JS
FAU - Oh, Chang Kyu
AU  - Oh CK
FAU - Kim, Tai Gyu
AU  - Kim TG
FAU - Choi, Hee Baeg
AU  - Choi HB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20071207
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Child, Preschool
MH  - DNA/analysis/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Korea/epidemiology
MH  - Mucocutaneous Lymph Node Syndrome/epidemiology/*genetics
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Retrospective Studies
PMC - PMC2267487
EDAT- 2007/12/08 09:00
MHDA- 2008/07/23 09:00
PMCR- 2008/03/14
CRDT- 2007/12/08 09:00
PHST- 2007/02/28 00:00 [received]
PHST- 2007/10/25 00:00 [accepted]
PHST- 2007/08/15 00:00 [revised]
PHST- 2007/12/08 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2007/12/08 09:00 [entrez]
PHST- 2008/03/14 00:00 [pmc-release]
AID - 9146 [pii]
AID - 10.1007/s00246-007-9146-3 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2008 Mar;29(2):402-8. doi: 10.1007/s00246-007-9146-3. Epub 2007 
      Dec 7.