PMID- 18064643 OWN - NLM STAT- MEDLINE DCOM- 20080107 LR - 20090112 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 50 IP - 2 Suppl DP - 2008 Feb TI - Body composition, exercise and energy expenditure in survivors of acute lymphoblastic leukaemia. PG - 456-61; discussion 468 AB - Survivors of acute lymphoblastic leukaemia (ALL) are recognised to become overweight and this seems to worsen with increasing length of follow up. Increases in body fat appear to be more marked in girls than in boys and in those who have received prophylactic cranial irradiation. Physiological responses to exercise, both at submaximal and maximal levels, are different in ALL survivors compared to controls. Heart rate appears to be increased at low intensity exercise, possibly to maintain adequate cardiac output. Maximal aerobic capacity is reduced, signifying a lower level of physical fitness. Total daily energy expenditure (TDEE) under free living conditions appears limited due to low participation in physical activity. Associations exist between measures of energy expenditure and body fat, but whether these are cause or effect has yet to proven. CI - (c) 2007 Wiley-Liss, Inc. FAU - Warner, Justin T AU - Warner JT AD - Department of Child Health, University Hospital of Wales, Cardiff, Wales, UK. justin.warner@cardiffandvale.wales.nhs.uk LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Pediatr Blood Cancer JT - Pediatric blood & cancer JID - 101186624 SB - IM MH - Adipose Tissue/metabolism MH - *Body Composition MH - *Energy Metabolism MH - Exercise/*psychology MH - Humans MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology MH - *Survivors RF - 28 EDAT- 2007/12/08 09:00 MHDA- 2008/01/08 09:00 CRDT- 2007/12/08 09:00 PHST- 2007/12/08 09:00 [pubmed] PHST- 2008/01/08 09:00 [medline] PHST- 2007/12/08 09:00 [entrez] AID - 10.1002/pbc.21411 [doi] PST - ppublish SO - Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):456-61; discussion 468. doi: 10.1002/pbc.21411.