PMID- 18065468
OWN - NLM
STAT- MEDLINE
DCOM- 20080522
LR  - 20240322
IS  - 1542-0086 (Electronic)
IS  - 0006-3495 (Print)
IS  - 0006-3495 (Linking)
VI  - 94
IP  - 6
DP  - 2008 Mar 15
TI  - How does intracellular Ca2+ oscillate: by chance or by the clock?
PG  - 2404-11
AB  - Ca2+ oscillations have been considered to obey deterministic dynamics for almost 
      two decades. We show for four cell types that Ca2+ oscillations are instead a 
      sequence of random spikes. The standard deviation of the interspike intervals 
      (ISIs) of individual spike trains is similar to the average ISI; it increases 
      approximately linearly with the average ISI; and consecutive ISIs are 
      uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using 
      Ca2+ buffers increases the average ISI and the standard deviation in agreement 
      with the idea that individual spikes are caused by random wave nucleation. 
      Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small 
      standard deviation of ISIs.
FAU - Skupin, Alexander
AU  - Skupin A
AD  - Department of Theoretical Physics, Hahn Meitner Institut, Berlin, Germany.
FAU - Kettenmann, Helmut
AU  - Kettenmann H
FAU - Winkler, Ulrike
AU  - Winkler U
FAU - Wartenberg, Maria
AU  - Wartenberg M
FAU - Sauer, Heinrich
AU  - Sauer H
FAU - Tovey, Stephen C
AU  - Tovey SC
FAU - Taylor, Colin W
AU  - Taylor CW
FAU - Falcke, Martin
AU  - Falcke M
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071207
PL  - United States
TA  - Biophys J
JT  - Biophysical journal
JID - 0370626
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Biophysics/*methods
MH  - Calcium/*metabolism
MH  - Calcium Signaling
MH  - Cell Membrane/*metabolism
MH  - Diffusion
MH  - Electrophysiology/methods
MH  - Humans
MH  - Models, Biological
MH  - Neurons
MH  - *Oscillometry
MH  - Stochastic Processes
PMC - PMC2257893
EDAT- 2007/12/11 09:00
MHDA- 2008/05/23 09:00
PMCR- 2009/03/15
CRDT- 2007/12/11 09:00
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/05/23 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
PHST- 2009/03/15 00:00 [pmc-release]
AID - S0006-3495(08)70583-6 [pii]
AID - 119495 [pii]
AID - 10.1529/biophysj.107.119495 [doi]
PST - ppublish
SO  - Biophys J. 2008 Mar 15;94(6):2404-11. doi: 10.1529/biophysj.107.119495. Epub 2007 
      Dec 7.