PMID- 18066575
OWN - NLM
STAT- MEDLINE
DCOM- 20080821
LR  - 20211020
IS  - 0340-0131 (Print)
IS  - 0340-0131 (Linking)
VI  - 81
IP  - 7
DP  - 2008 Jul
TI  - Influence of glutathione-related genes on symptoms and immunologic markers among 
      vulcanization workers in the southern Sweden rubber industries.
PG  - 913-9
AB  - OBJECTIVE: The aim was to elucidate the role of genetic variants on symptoms of 
      the eyes and airways, headache and nausea, as well as on immunologic markers, 
      among vulcanization workers in the contemporary Swedish rubber industry. 
      Polymorphisms in genes, which are involved in the defense against reactive oxygen 
      species and metabolism of toxic substances present in the vulcanization fumes, 
      were analyzed. METHODS: One hundred and forty-five exposed and 117 unexposed 
      workers were included in the study. Medical and occupational histories were 
      obtained in structured interviews. Symptoms were recorded and immunologic markers 
      analyzed in blood. Polymorphisms in glutathione-related genes (glutamate cysteine 
      ligase catalytic subunit (GCLC)-129, glutamate cysteine ligase modifier subunit 
      (GCLM)-588, glutathione S-transferase alpha 1 (GSTA1)-52, GSTM1*O, GSTP1-105, 
      GSTP1-114, and GSTT1*O) were analyzed by Taqman-based allelic discrimination and 
      ordinary PCR. RESULTS: A protective effect of GSTA1-52 (G/A + A/A) genotype on 
      symptoms and immunologic cells, in particular among exposed workers, was 
      suggested. Exposed workers with GSTT1*O had increased risk of nosebleed compared 
      to exposed workers with GSTT1*1. Exposed workers with GSTP1-105 (ile/val + 
      val/val) had decreased levels of total immunoglobulin E (IgE) compared to exposed 
      workers with GSTP1-105 ile/ile. GCLC-129 variant genotype demonstrated increased 
      levels of immunologic cells among exposed workers, although statistical 
      significance was not reached. CONCLUSION: Our data indicate that hereditary 
      factors influence the susceptibility to symptoms and the immunologic response of 
      workers in the rubber industry.
FAU - Jonsson, Lena S
AU  - Jonsson LS
AD  - Division of Occupational and Environmental Medicine, University Hospital, 221 85, 
      Lund, Sweden. lena_s.jonsson@med.lu.se
FAU - Jonsson, Bo A G
AU  - Jonsson BA
FAU - Axmon, Anna
AU  - Axmon A
FAU - Littorin, Margareta
AU  - Littorin M
FAU - Broberg, Karin
AU  - Broberg K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071208
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-04-6 (Rubber)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Air Pollutants, Occupational/adverse effects/*immunology
MH  - Analysis of Variance
MH  - Biomarkers/*analysis/urine
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunoglobulin E/analysis
MH  - Industry
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
MH  - Odds Ratio
MH  - Polymorphism, Genetic/genetics
MH  - Rubber
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2007/12/11 09:00
MHDA- 2008/08/22 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/06/28 00:00 [received]
PHST- 2007/11/14 00:00 [accepted]
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/08/22 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - 10.1007/s00420-007-0285-x [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2008 Jul;81(7):913-9. doi: 
      10.1007/s00420-007-0285-x. Epub 2007 Dec 8.